| Spiral arterial remodeling is not essential for normal blood pressure regulation in pregnant mice. | |
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MedLine Citation:
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PMID: 20100997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal cardiovascular adaptations occur in normal pregnancy, systemically, and within the uterus. In humans, gestational control of blood pressure is clinically important. Transient structural remodeling of endometrial spiral arteries normally occurs in human and mouse pregnancies. In mice, this depends on uterine natural killer cell function. Using normal and immune-deficient mice, we asked whether spiral artery remodeling critically regulates gestational mean arterial pressure and/or placental growth. Radiotelemetric transmitters were implanted in females and hemodynamic profiles to a dietary salt challenge and to pregnancy were assessed. Implantation sites from noninstrumented females were used for histological morphometry. Both normal and immune-deficient mice had normal sensitivity to salt and showed similar 5-phase gestational patterns of mean arterial pressure correlating with stages of placental development, regardless of spiral artery modification. After implantation, mean arterial pressure declined during the preplacental phase to reach a midgestation nadir. With gestation day 9 opening of placental circulation, pressure rose, reaching baseline before parturition, whereas heart rate dropped. Heart rate stabilized before parturition. Placental sizes deviated during late gestation when growth stopped in normal mice but continued in immune-deficient mice. As an indication of the potential for abnormal hemodynamics, 2 pregnant females delivering dead offspring developed late gestational hypertension. This study characterizes a dynamic pattern of blood pressure over mouse pregnancy that parallels human gestation. Unexpectedly, these data reveal that spiral artery remodeling is not required for normal gestational control of blood pressure or for normal placental growth. |
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Authors:
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Suzanne D Burke; Valérie F Barrette; Juares Bianco; Julie G Thorne; Aureo T Yamada; Stephen C Pang; Michael A Adams; B Anne Croy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Hypertension Volume: 55 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-03-18 Revised Date: 2010-10-06 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 729-37 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Queen's University, Kingston, ON K7L 3N6, Canada. suzanne.burke@queensu.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Arteries / physiology* Blood Pressure / physiology* Blood Pressure Monitors DNA-Binding Proteins / genetics Female Immune System Diseases / genetics, physiopathology* Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Mutant Strains Placenta / physiology Pregnancy Pregnancy Outcome Pregnancy, Animal / physiology* Sodium Chloride, Dietary / pharmacology Telemetry |
| Grant Support | |
ID/Acronym/Agency:
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77519//Canadian Institutes of Health Research; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Rag2 protein, mouse; 0/Sodium Chloride, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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