| Spiradenomas in Brooke-Spiegler syndrome. | |
| | |
MedLine Citation:
|
PMID: 7684205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Brooke-Spiegler syndrome is an autosomal dominantly inherited disease characterized by the development of multiple trichoepitheliomas and cylindromas. Among other neoplasms that may also occur in Brooke-Spiegler syndrome are basal cell carcinomas and spiradenomas. Spiradenomas and cylindromas have so many features in common that they have been regarded as variants of the same neoplasm. This assumption was supported by the occurrence of both types of lesions in Brooke-Spiegler syndrome. We report a case of Brooke-Spiegler syndrome in which spiradenomas were found in the immediate vicinity of trichoepitheliomas and in continuity with follicles. Because of the embryonic relationship between follicles and apocrine glands, these features indicate that spiradenomas are apocrine neoplasms. We conclude that Brooke-Spiegler syndrome is an inherited disease that affects the folliculosebaceous apocrine unit. |
| | |
Authors:
|
W Weyers; M Nilles; F Eckert; W B Schill |
Related Documents
:
|
1856835 - Cardiac rhabdomyomata and megacystis-microcolon-intestinal hypoperistalsis syndrome. 6713925 - Computed tomography of mural thrombosis in the hypereosinophilic syndrome. 577975 - Treatment of bechçet's syndrome with transfer factor. 21204215 - Arx polyalanine expansions are highly implicated in familial cases of mental retardatio... 21417595 - After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndro... 22470675 - Ct and 111in-pentetreotide spect of hilar acth-producing neuroendocrine tumor associate... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The American Journal of dermatopathology Volume: 15 ISSN: 0193-1091 ISO Abbreviation: Am J Dermatopathol Publication Date: 1993 Apr |
Date Detail:
|
Created Date: 1993-06-17 Completed Date: 1993-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 156-61 Citation Subset: IM |
Affiliation:
|
Center of Dermatology and Andrology, Justus Liebig University, Giessen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma, Sweat Gland
/
pathology* Adult Carcinoembryonic Antigen / analysis Carcinoma, Adenoid Cystic / pathology* Cell Nucleus / ultrastructure Cytoplasm / ultrastructure Facial Neoplasms / pathology* Female Humans Keratins / analysis Neoplasms, Multiple Primary / pathology* Neoplastic Syndromes, Hereditary / pathology* S100 Proteins / analysis Skin Neoplasms / pathology* |
| Chemical | |
Reg. No./Substance:
|
0/Carcinoembryonic Antigen; 0/S100 Proteins; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prostate marker immunoreactivity in salivary gland neoplasms. A rare pitfall in immunohistochemistry...
Next Document: Tandem time-of-flight mass spectrometer.