| Spiperone binding capacity in lymphocytes of patients with alcohol- and drug-induced psychosis: preliminary results. | |
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MedLine Citation:
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PMID: 7934059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased spiperone binding capacity in lymphocytes has been proposed as a possible biological marker for schizophrenia while in previous studies patients with alcohol dependence were shown to have a normal binding capacity. In a pilot study the spiperone binding capacity was studied in 8 patients with alcohol hallucinosis, 11 patients with acute drug-induced psychosis and 12 patients with other organic psychosis. An increased binding capacity, defined as > 4 fmol/l E6 cells, was found in only 1 patient with alcohol hallucinosis, 3 patients with drug-induced psychosis and 2 patients with other organic psychosis. Possible implications of these findings for future research are discussed. |
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Authors:
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M Soyka; B Bondy; B Peuker; M Ackenheil |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of studies on alcohol Volume: 55 ISSN: 0096-882X ISO Abbreviation: J. Stud. Alcohol Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-11-07 Completed Date: 1994-11-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503813 Medline TA: J Stud Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 503-7 Citation Subset: IM |
Affiliation:
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Psychiatische Klinik und Poliklinik, Universität München, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Delirium, Dementia, Amnestic, Cognitive Disorders / blood, diagnosis Diagnosis, Differential Female Hallucinations / blood, diagnosis Humans Lymphocytes / metabolism Male Middle Aged Pilot Projects Psychoses, Alcoholic / blood, diagnosis* Psychoses, Substance-Induced / blood, diagnosis* Receptors, Dopamine / metabolism* Risk Factors Schizophrenia / blood, diagnosis Spiperone / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 0/spiroperidol receptor; 749-02-0/Spiperone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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