| Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. | |
| | |
MedLine Citation:
|
PMID: 11135647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally. |
| | |
Authors:
|
D Andrew; A D Craig |
Related Documents
:
|
17390127 - Early cortical activities evoked by noxious stimulation in humans. 21414907 - Imaging light responses of targeted neuron populations in the rodent retina. 20660417 - Abnormal activity of primary somatosensory cortex in central pain syndrome. 3797017 - Convergence of cutaneous, tooth pulp, visceral, neck and muscle afferents onto nocicept... 15210117 - Taste representations in the drosophila brain. 11189027 - Neural and humoral pathways of communication from the immune system to the brain: paral... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Nature neuroscience Volume: 4 ISSN: 1097-6256 ISO Abbreviation: Nat. Neurosci. Publication Date: 2001 Jan |
Date Detail:
|
Created Date: 2001-01-26 Completed Date: 2001-02-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 72-7 Citation Subset: IM |
Affiliation:
|
Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, 350 W. Thomas Road, Phoenix, Arizona 85013, USA. dandrew@chw.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cats Histamine Iontophoresis Lumbosacral Region Mustard Plant Nerve Fibers / physiology Neural Conduction / physiology Neural Pathways / physiology* Neurons, Afferent / classification, cytology, physiology* Pain Measurement Plant Extracts Plant Oils Pruritus* / chemically induced, physiopathology Spinothalamic Tracts / cytology, physiology* Stimulation, Chemical Temperature Sense / physiology Thalamus / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
NS 25616/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Plant Extracts; 0/Plant Oils; 51-45-6/Histamine; 8007-40-7/mustard oil |
| Comments/Corrections | |
Comment In:
|
Nat Neurosci. 2001 Jan;4(1):9-10
[PMID:
11135635
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dendritic coincidence detection of EPSPs and action potentials.
Next Document: Loudness constancy with varying sound source distance.