Document Detail


Spinosad resistance in female Musca domestica L. from a field-derived population.
MedLine Citation:
PMID:  21681919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bait-formulated spinosad is currently being introduced for housefly (Musca domestica L.) control around the world. Spinosad resistance was evaluated in a multiresistant field population and strains derived from this by selection with insecticides. Constitutive and spinosad-induced expression levels of three cytochrome P450 genes, CYP6A1, CYP6D1 and CYP6D3, previously reported to be involved in insecticide resistance, were examined.
RESULTS: In 2004 a baseline for spinosad toxicity of Danish houseflies where all field populations were considered to be susceptible was established. In the present study, females of a multiresistant field population 791a were, however, 27-fold spinosad resistant at LC(50), whereas 791a male houseflies were susceptible. Strain 791a was selected with spinosad, thiamethoxam, fipronil and imidacloprid, resulting in four strains with individual characteristics. Selection of 791a with spinosad did not alter spinosad resistance in either males or females, but counterselected against resistance to the insecticides thiamethoxam and imidacloprid targeting nicotinic acetylcholine receptors. A synergist study with piperonyl butoxide, as well as gene expression studies of CYP6A1, CYP6D1 and CYP6D3, indicated a partial involvement of cytochrome P450 genes in spinosad resistance.
CONCLUSION: This study reports female-linked spinosad resistance in Danish houseflies. Negative cross-resistance was observed between spinosad and neonicotinoids in one multiresistant housefly strain. Spinosad resistance involved alterations of cytochrome P450 gene expression.
Authors:
Mette D K Markussen; Michael Kristensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-16
Journal Detail:
Title:  Pest management science     Volume:  68     ISSN:  1526-4998     ISO Abbreviation:  Pest Manag. Sci.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-03-30     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  100898744     Medline TA:  Pest Manag Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Chemical Industry.
Affiliation:
Department of Integrated Pest Management, Aarhus University, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Combinations
Female
Gene Expression / drug effects
Houseflies / drug effects*,  genetics,  metabolism
Insect Proteins / genetics,  metabolism
Insecticide Resistance*
Insecticides / pharmacology*
Macrolides / pharmacology*
Male
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Insect Proteins; 0/Insecticides; 0/Macrolides; 0/spinosad
Comments/Corrections
Erratum In:
Pest Manag Sci. 2012 Jun;68(6):958

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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