Document Detail


Spindles, mitochondria and redox potential in ageing oocytes.
MedLine Citation:
PMID:  14759287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of human oocytes obtained from women of advanced reproductive age revealed that spindles are frequently aberrant, with chromosomes sometimes failing to align properly at the equator during meiosis I and II. Chromosomal analyses of donated and spare human oocytes and cytogenetic and molecular studies on the origin of trisomies collectively suggest that errors in chromosome segregation during oogenesis increase with advancing maternal age and as the menopause approaches. Disturbances in the fidelity of chromosome segregation, especially at anaphase I, leading to aneuploidy are prime causes of reduced developmental competence of embryos in assisted reproduction, as well as being responsible for the genesis of genetic disease. This review provides an overview of spindle formation and chromosome behaviour in mammalian oocytes. Evidence of a link between abnormal mitochondrial function in oocytes and somatic follicular cells, and finally disturbances in chromosome cohesion and segregation, and cell cycle control in aged mammalian oocytes, are also discussed.
Authors:
U Eichenlaub-Ritter; E Vogt; H Yin; R Gosden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  8     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-58     Citation Subset:  IM    
Affiliation:
Institute of Gene Technology/Microbiology, Faculty of Biology, University of Bielefeld, D-33501 Bielefeld, Germany. eiri@uni-bielefeld.de
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Animals
Cell Aging / physiology
Chromosome Segregation
Female
Humans
Mitochondria / physiology*
Mitotic Spindle Apparatus / physiology*
Oocytes / physiology*
Oxidation-Reduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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