Document Detail


Spindles get the ran around.
MedLine Citation:
PMID:  10603469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its fundamental role in cell division, the mitotic spindle remains an enigmatic figure in cell biology. This is due to the complex dynamic behaviour of microtubules, which form the spindle fibres responsible for segregating chromosomes to opposite ends of the cell during mitosis. Recent reports indicate that the small GTPase Ran, which plays a key role in nuclear transport, also has a role in mitosis by regulating microtubule nucleation and/or growth. The race is now on to determine how Ran exerts its effects on spindle assembly.
Authors:
R Heald; K Weis
Related Documents :
18239929 - Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic...
7251659 - Tubulin pools in differentiating neuroblastoma cells.
12058019 - The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends...
20566439 - Effect of inganen anticancer properties on microtobule organization.
19460099 - Dbf2 is essential for cytokinesis and correct mitotic spindle formation in candida albi...
19164929 - Centriole inheritance.
23421999 - Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive...
1543899 - Characterization of n-myc amplification in a human neuroblastoma cell line by clones is...
22471369 - Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colore...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  10     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. heald@socrates.berkeley.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Microtubules
Mitosis*
Mitotic Spindle Apparatus*
ran GTP-Binding Protein*
Chemical
Reg. No./Substance:
EC 3.6.5.2/ran GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monitor: progress and profiles.
Next Document:  Sorting nuclear membrane proteins at mitosis.