Document Detail


Spindles get the ran around.
MedLine Citation:
PMID:  10603469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its fundamental role in cell division, the mitotic spindle remains an enigmatic figure in cell biology. This is due to the complex dynamic behaviour of microtubules, which form the spindle fibres responsible for segregating chromosomes to opposite ends of the cell during mitosis. Recent reports indicate that the small GTPase Ran, which plays a key role in nuclear transport, also has a role in mitosis by regulating microtubule nucleation and/or growth. The race is now on to determine how Ran exerts its effects on spindle assembly.
Authors:
R Heald; K Weis
Related Documents :
17228329 - Spindle regulation in neural precursors of flies and mammals.
8714689 - Effects of taxol on the polymerization and posttranslational modification of class iii ...
2826509 - Turnover of the carboxy-terminal tyrosine of alpha-tubulin and means of reaching elevat...
9150749 - Interference with microtubules and induction of micronuclei in vitro by various bisphen...
16546079 - Making microtubules and mitotic spindles in cells without functional centrosomes.
3095609 - Evaluation of pseudomonas aeruginosa influence on the cytoskeleton of hep-2 cells.
17706789 - Increased cell suspension concentration augments the survival rate of grafted tyrosine ...
15519759 - Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuro...
23300249 - Characterization of a diffusible signaling factor from xylella fastidiosa.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  10     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. heald@socrates.berkeley.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Microtubules
Mitosis*
Mitotic Spindle Apparatus*
ran GTP-Binding Protein*
Chemical
Reg. No./Substance:
EC 3.6.5.2/ran GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monitor: progress and profiles.
Next Document:  Sorting nuclear membrane proteins at mitosis.