Document Detail

Spindles get the ran around.
MedLine Citation:
PMID:  10603469     Owner:  NLM     Status:  MEDLINE    
Despite its fundamental role in cell division, the mitotic spindle remains an enigmatic figure in cell biology. This is due to the complex dynamic behaviour of microtubules, which form the spindle fibres responsible for segregating chromosomes to opposite ends of the cell during mitosis. Recent reports indicate that the small GTPase Ran, which plays a key role in nuclear transport, also has a role in mitosis by regulating microtubule nucleation and/or growth. The race is now on to determine how Ran exerts its effects on spindle assembly.
R Heald; K Weis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  10     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.
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MeSH Terms
Mitotic Spindle Apparatus*
ran GTP-Binding Protein*
Reg. No./Substance:
EC GTP-Binding Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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