Document Detail

Spindle regulation in neural precursors of flies and mammals.
MedLine Citation:
PMID:  17228329     Owner:  NLM     Status:  MEDLINE    
The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.
Joshua J Buchman; Li-Huei Tsai
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-01-17
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  8     ISSN:  1471-003X     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-100     Citation Subset:  IM    
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
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MeSH Terms
Cell Cycle Proteins / physiology
Diptera / cytology
Mitotic Spindle Apparatus / physiology*
Models, Biological
Neurons / cytology*
Stem Cells / physiology*
Reg. No./Substance:
0/Cell Cycle Proteins

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