| Spindle cell carcinoma of the larynx. | |
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MedLine Citation:
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PMID: 1139427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A clinicopathologic correlation of 39 cases of a histologically biphasic malignant neoplasm of the larynx is presented. The histologic pattern of this entity was mainly that of a malignant spindle cell process, but a definite squamous cell carcinoma component was evident. Grossly the tumors were usually prominently polypoid. A morphologic transition of the squamous cell carcinomatous element into the spindle cell component was strongly suggested, supporting the contention that this entity is pathogenetically a pleomorphic or spindle cell squamous cell carcinoma. Follow-up information on 20 cases indicated a two-year mortality of 40 per cent, refuting the contention that this entity is of low-grade malignancy. Complete surgical removal of the neoplasm, with or without irradiation, offered the best therapeutic approach. Irradiation alone was unsuccessful. |
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Authors:
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V J Hyams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of otolaryngology. Journal canadien d'otolaryngologie Volume: 4 ISSN: 0045-5083 ISO Abbreviation: Can J Otolaryngol Publication Date: 1975 |
Date Detail:
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Created Date: 1975-10-10 Completed Date: 1975-10-10 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 7610409 Medline TA: Can J Otolaryngol Country: CANADA |
Other Details:
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Languages: eng Pagination: 307-13 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma / etiology, pathology* Carcinoma, Squamous Cell / etiology, pathology* Continental Population Groups Female Humans Laryngeal Neoplasms / etiology, pathology* Laryngectomy Larynx / ultrastructure Lymphatic Metastasis Male Middle Aged Neck Dissection |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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