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Spindle Epithelial Tumor with Thymus-like Differentiation (SETTLE): A Case Report and Comprehensive Review of the Literature and Treatment Options.
MedLine Citation:
PMID:  24677409     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare cancer of thymic origin with little information available for treating clinicians. Methods. We performed a comprehensive literature search and updates were requested from all authors. We report one recent case. Results. We present the most comprehensive review of the clinical literature for SETTLE. We identified 41 published cases.SETTLE usually presents as an asymptomatic neck mass. Most patients successfully underwent surgical resection of the primary tumor. The mean latency to develop metastasis was 10 years. SETTLE is uniformly responsive to radiotherapy and combination chemotherapy in the rare cases where response data are available. Conclusion. Although SETTLE is initially indolent, it has the capacity to metastasize late in its course. The malignant potential of this tumor might be underestimated due to the lack of long-term follow-up. In cases where complete surgical resection is not possible, radiotherapy or combination chemotherapy is effective. Head Neck, 2014.
Authors:
Gonzalo Recondo; Naifa Busaidy; Jeremy Erasmus; Michelle D Williams; Faye M Johnson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-20
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., A Wiley Company.
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