Document Detail

Spinal non-Hodgkin's lymphoma mimicking a flare of disease in a patient with ankylosing spondylitis treated with anti-TNF agents: case report and review of the literature.
MedLine Citation:
PMID:  24699989     Owner:  NLM     Status:  Publisher    
We report the case of a 52-year-old man with long-standing HLAB27-positive ankylosing spondylitis treated with anti-tumour necrosis factor (TNF) alpha therapy who was admitted to our rheumatology department complaining of increasing lumbar and buttock pain radiating to the posterior thigh, associated with numbness in the leg, gait disturbance and low-grade fever. The clinical picture was initially interpreted as a flare of disease but was not responsive to treatment. A contrast-enhanced spinal MRI was performed with evidence of a diffuse signal abnormality involving the sacroiliac joints and the spine, with evidence of spondylodiscitis of L5 and with a lesion causing L5-S1 root compression and infiltrating the iliopsoas muscle. These findings confirmed the possibility of a reactivation of disease associated with an infectious process. The most frequent causes of infectious spondylodiscitis were excluded, and a biopsy was then performed. Histological analysis revealed a high-grade B-cell non-Hodgkin's lymphoma of the spine. This case highlights how a differential diagnosis of low back pain with neurological symptoms can be particularly troublesome in ankylosing spondylitis and that continuous vigilance is warranted in patients treated with long-term immunosuppressive therapies.
Sara Monti; Nicola Boffini; Marco Lucioni; Marco Paulli; Carlomaurizio Montecucco; Roberto Caporali
Related Documents :
25191669 - Review of the literature on necrotizing sialometaplasia and case presentation.
25386319 - Zosteriform metastases from colon carcinoma: an unusual pattern.
11466149 - Aortic transsection after blunt chest trauma.
19916899 - Acute dysphagia associated with aortic dissection: a case report and review of the lite...
24015139 - Bronchoscopy as a rescue therapy in patients with status asthmaticus: two case reports ...
24332929 - Reconstruction of upper lip avulsion after dog bite: case report and review of literature.
17989769 - Spinal stenosis: a summary and review.
22280859 - From identification and review to action-maternal mortality review in the united states.
15839359 - Familial median canaliform nail dystrophy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-5
Journal Detail:
Title:  Clinical rheumatology     Volume:  -     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical radiobiology of glioblastoma multiforme : Estimation of tumor control probability from vari...
Next Document:  Core-shell inversion by pH modulation in dynamic covalent micelles.