Document Detail


Spinal muscular atrophy: manifestations and management.
MedLine Citation:
PMID:  22661569     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by a homozygous deletion in the SMN1 gene and is manifested by loss of the anterior horn cells of the spinal cord. Classifications of the disorder are based on age of onset and the patient's level of function. Scoliosis and hip subluxation or dislocation are two musculoskeletal manifestations associated with SMA. Severity of scoliosis correlates with age at presentation. Bracing has been unsuccessful in halting curve progression and may interfere with respiratory effort. Early onset scoliosis associated with SMA has been successfully treated with growing rod constructs, and posterior spinal fusion can be used in older children. Hip subluxations and dislocations are best treated nonsurgically if the patient reports no pain because a high rate of recurrent dislocation has been reported with surgical intervention.
Authors:
Addisu Mesfin; Paul D Sponseller; Arabella I Leet
Related Documents :
16609129 - Complementary and alternative medicine for functional gastrointestinal disorders.
23147349 - Temporomandibular disorders in scuba divers-an increased risk during diving certificati...
23697819 - Assessing psychopathology from a structural perspective: a psychodynamic model.
23066769 - Effects of n-acetyl cysteine on cognitive function in bipolar disorder.
23373609 - Posterior cortical atrophy: a case study of benson's syndrome that initially presented ...
23953929 - Acute glucocorticoid effects on response inhibition in borderline personality disorder.
12409159 - Phosphorus metabolite changes in temporal lobes of subjects with schizotypal personalit...
21397109 - The diagnosis and treatment of attention deficit-hyperactivity disorder in children and...
22183089 - Olfaction in child and adolescent anorexia nervosa.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the American Academy of Orthopaedic Surgeons     Volume:  20     ISSN:  1067-151X     ISO Abbreviation:  J Am Acad Orthop Surg     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417468     Medline TA:  J Am Acad Orthop Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  393-401     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Implantable sensor technology: from research to clinical practice.
Next Document:  Modern Metal-on-Metal Hip Implants.