Document Detail

Spinal infection caused by ESBL-producing Klebsiella pneumoniae treated with temocillin.
MedLine Citation:
PMID:  18804871     Owner:  NLM     Status:  MEDLINE    
A case of cervical epidural abscess in a 63-year-old woman with a complex gastrointestinal surgical history is reported. The presenting symptom was neck pain, and blood analysis demonstrated raised erythrocyte sedimentation rate and C-reactive protein. MR imaging of the cervical spine revealed cervical discitis, osteomyelitis, and epidural collection. An ESBL-producing strain of Klebsiella pneumoniae, isolated from a previous episode of bacteraemia, was the causative organism. Surgical treatment was not possible and initial carbapenem therapy was aborted due to development of neutropaenia, and treatment continued with an extended course of temocillin. After 12 weeks of antibiotics the patient was pain-free with radiological improvement and resolution of blood markers of infection.
Edward Barton; Paul Flanagan; Simon Hill
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-09-19
Journal Detail:
Title:  The Journal of infection     Volume:  57     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
Department of Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Cervical Vertebrae* / microbiology
Discitis / drug therapy*,  microbiology
Epidural Abscess / drug therapy*,  microbiology
Klebsiella Infections / drug therapy,  microbiology
Klebsiella pneumoniae / drug effects,  enzymology*
Middle Aged
Osteomyelitis / drug therapy*,  microbiology
Penicillins / therapeutic use*
Treatment Outcome
beta-Lactam Resistance
beta-Lactamases / biosynthesis
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Penicillins; 61545-06-0/temocillin; EC

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