| Spinal haemorrhage during anticoagulant regimen for thromboprophylaxis: a unique form of central nervous system haemorrhage. | |
| | |
MedLine Citation:
|
PMID: 22566595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: The management of anticoagulation (AC) therapy in patients with central nervous system (CNS) haemorrhage remains challenging. This study examines the potential factors associated with spinal haematoma among patients who develop CNS haemorrhage while on AC therapy. METHODS: Based on a systematic review using MEDLINE and EMBASE, two reviewers screened publications and extracted data on all CNS-haemorrhage cases. First, all cases were grouped into brain, posterior fossa and spinal haemorrhage. Second, the spinal-haemorrhage group was subdivided into those patients experiencing complete neurological recovery, incomplete recovery, no recovery and death. Finally, axonal survival and inflammatory response after spinal cord injury (SCI) due to trauma and spinal haemorrhage were examined using postmortem spinal cord tissue. RESULTS: Data were extracted from 72 publications including 553 patients. There were significant differences among the CNS groups regarding patient characteristics and management, while their outcomes were comparable. Outcomes among the spinal-haemorrhage subgroups were not associated with patient characteristics and management. Postmortem examination of spinal cord showed that axonal survival and inflammatory response in a spinal-haemorrhage case were similar to a case of traumatic SCI. CONCLUSIONS: The results of this study suggest that the management of patients with spinal haemorrhage considerably differ from individuals with an intracranial haemorrhage during AC. However, survival and neurological recovery appear to be comparable among the CNS groups. The studied factors failed to discriminate the patient subgroups according to survival and neurological recovery. Finally, the neuropathology result reinforces the possibility that the mechanism of SCI may not be relevant for axonal survival and inflammatory response within the spinal cord. |
| | |
Authors:
|
Julio C Furlan; Gregory W Hawryluk; James Austin; Michael G Fehlings |
Related Documents
:
|
2125745 - The effect of l-glutamine and sodium intake in cystinuric patients. 3031435 - Adrenergic receptor hyperactivity--a cause for pseudopheochromocytoma? 904035 - Struvite staghorn calculi in crossed fused ectopia. 22888485 - Treatment of smell loss with systemic methylprednisolone. 6982905 - Alpha-1-antitrypsin phenotypes in malignant lymphoma. 23100955 - Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblasti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-05-07 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 83 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-06-05 Completed Date: 2012-08-16 Revised Date: 2012-12-07 |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 746-52 Citation Subset: IM |
Affiliation:
|
Toronto Western Research Institute, Toronto, Ontario, Canada. jcfurlan@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anticoagulants / adverse effects*, therapeutic use Hemorrhage / chemically induced*, pathology Humans Intracranial Hemorrhages / chemically induced, etiology Male Myelitis / complications, pathology Spinal Cord / pathology Spinal Cord Diseases / chemically induced*, etiology, pathology Spinal Cord Injuries / complications, pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral scler...
Next Document: Outcome and its predictors in Guillain-Barre syndrome.