| Spinal epidural hematoma following tissue plasminogen activator and heparinization for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 12227717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case of a 43-year-old Taiwanese man who presented with spinal epidural hematoma following intravenous administration of recombinant tissue plasminogen activator (rTPA) and heparin therapy for acute myocardial infarction (AMI) is reported. Upper back pain and progressive neurological dysfunction ensued, secondary to spinal epidural hematoma with spinal cord compression. The patient did not recover neurologic function postsurgically, possibly because the operation was delayed. In conclusion, cardiologists should be alert to this rare, severe complication of rTPA and should perform early laminectomy (in < or = 36 hours for those with complete deficit and in < or = 48 hours for those with incomplete deficit) if possible. |
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Authors:
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Kuei-Chuan Chan; Der-Jinn Wu; Kwo-Chang Ueng; Cheng-Sheng Lin; Chin-Feng Tsai; Kwo-Shuen Chen; Ming-Cheng Lin; Kao-Lun Wang; Chung-Sheng Lin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 43 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-09-13 Completed Date: 2002-10-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: Japan |
Other Details:
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Languages: eng Pagination: 417-21 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Hematoma, Epidural, Cranial / chemically induced* Heparin / administration & dosage, adverse effects* Humans Male Myocardial Infarction / drug therapy* Recombinant Proteins / administration & dosage, adverse effects Spinal Cord Diseases / chemically induced Tissue Plasminogen Activator / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 9005-49-6/Heparin; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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