Document Detail

Spinal epidural hematoma following tissue plasminogen activator and heparinization for acute myocardial infarction.
MedLine Citation:
PMID:  12227717     Owner:  NLM     Status:  MEDLINE    
The case of a 43-year-old Taiwanese man who presented with spinal epidural hematoma following intravenous administration of recombinant tissue plasminogen activator (rTPA) and heparin therapy for acute myocardial infarction (AMI) is reported. Upper back pain and progressive neurological dysfunction ensued, secondary to spinal epidural hematoma with spinal cord compression. The patient did not recover neurologic function postsurgically, possibly because the operation was delayed. In conclusion, cardiologists should be alert to this rare, severe complication of rTPA and should perform early laminectomy (in < or = 36 hours for those with complete deficit and in < or = 48 hours for those with incomplete deficit) if possible.
Kuei-Chuan Chan; Der-Jinn Wu; Kwo-Chang Ueng; Cheng-Sheng Lin; Chin-Feng Tsai; Kwo-Shuen Chen; Ming-Cheng Lin; Kao-Lun Wang; Chung-Sheng Lin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  43     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Department of Internal Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Hematoma, Epidural, Cranial / chemically induced*
Heparin / administration & dosage,  adverse effects*
Myocardial Infarction / drug therapy*
Recombinant Proteins / administration & dosage,  adverse effects
Spinal Cord Diseases / chemically induced
Tissue Plasminogen Activator / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Recombinant Proteins; 9005-49-6/Heparin; EC Plasminogen Activator

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