| Spinal cord ring enhancement in multiple sclerosis. | |
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MedLine Citation:
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PMID: 21060017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the clinical and imaging characteristics of spinal cord ring enhancement in multiple sclerosis (MS). DESIGN: Clinical case series. SETTING: Academic referral center. PATIENTS: Twenty patients with MS who had spinal cord ring enhancement were retrospectively identified from 322 cervical and thoracic spinal cord magnetic resonance imaging studies during a 3-year period. MAIN OUTCOME MEASURES: Demographics, disability, and pattern of enhancement on spinal cord and concomitant brain magnetic resonance imaging results. RESULTS: Ring enhancement was seen in 20 patients with spinal cord enhancement, most commonly in the cervical cord. Incomplete or "open" ring enhancement was the dominant pattern in 19 of the 20 patients (95%). Concurrent enhancing brain lesions were present in 14 patients, 8 of which (57%) exhibited a ring pattern of enhancement. At the time of imaging, the Expanded Disability Status Scale scores ranged from 1.0 to 7.0 (median score, 3.0). CONCLUSIONS: Ring enhancement is not an uncommon pattern for spinal cord lesions in MS, occurring with a prevalence of 6.2% (20 of 322 imaging studies). The most common pattern is incomplete ring enhancement in the cervical spinal cord. Recognition of this pattern may improve and expedite the diagnosis of MS and preclude the need for invasive diagnostic interventions. |
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Authors:
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Eric C Klawiter; Tammie Benzinger; Abhik Roy; Robert T Naismith; Becky Jo Parks; Anne H Cross |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of neurology Volume: 67 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2010-12-15 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1395-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Washington University, St Louis, Missouri, USA. eklawiter@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology* Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / pathology* Spinal Cord / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS052430-01A1/NS/NINDS NIH HHS; K23NS052430-01A1/NS/NINDS NIH HHS; UL1 RR024992-02/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS |
| Comments/Corrections | |
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