Document Detail

Spinal cord compression by secondary epi- and intradural metastases in childhood.
MedLine Citation:
PMID:  9298274     Owner:  NLM     Status:  MEDLINE    
Over a 9-year period, 35 out of 614 children with malignant tumours who were treated at the Centre Léon Bérard developed spinal metastases. Of these, 18 with known malignancies before the development of spinal cord compression are reviewed. The most common tumours causing spinal metastases were Ewing's sarcoma, neuroblastoma and renal tumours. Cord compression occurred 5-88 months after the diagnosis of systemic cancer. The median interval from first symptoms to the diagnosis of compression was 17 days. There were 16 patients with neurological deficit, including 5 with paraplegia. Specific imaging procedures were performed in 16 patients. Treatment included operation in 8 patients, followed by chemotherapy (6 patients) and/or radiotherapy (4 patients); 9 of the 10 non-operated patients received radiotherapy. Only 6 patients had a significant neurological improvement. All patients but 1 died within a median time of 2 months. Early diagnosis might prevent permanent disability in these children with a short survival expectancy.
E Bouffet; P Marec-Berard; P Thiesse; C Carrie; T Risk; A Jouvet; M Brunat-Mentigny; C Mottolese
Related Documents :
19515614 - Predicting outcomes for children with neuroblastoma using a multigene-expression signat...
9212844 - Trends of survival in neuroblastoma and independent risk factors for survival at a sing...
1779334 - Urinary dopamine/noradrenaline and dopamine/vanillylmandelic acid ratios as a reflectio...
1625134 - Therapeutic significance of surgery in advanced neuroblastoma: a report from the study ...
23108554 - Nuclear e-cadherin expression is associated with the loss of membranous e-cadherin, pla...
9140434 - Suramin in non-small cell lung cancer and advanced breast cancer. two parallel phase ii...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  13     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  IM    
Department of Paediatric Oncology, Centre Léon Bérard, Lyon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Neoplasms / pathology
Brain Neoplasms / pathology
Child, Preschool
Kidney Neoplasms / pathology
Neoplasm Staging
Retrospective Studies
Spinal Cord Compression / etiology*
Spinal Cord Neoplasms / complications*,  drug therapy,  secondary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Spinal cord astrocytomas: long-term results comparing treatments in children.
Next Document:  Prognosis of medulloblastoma in infants.