| Spinal cord compression by secondary epi- and intradural metastases in childhood. | |
MedLine Citation:
|
PMID: 9298274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Over a 9-year period, 35 out of 614 children with malignant tumours who were treated at the Centre Léon Bérard developed spinal metastases. Of these, 18 with known malignancies before the development of spinal cord compression are reviewed. The most common tumours causing spinal metastases were Ewing's sarcoma, neuroblastoma and renal tumours. Cord compression occurred 5-88 months after the diagnosis of systemic cancer. The median interval from first symptoms to the diagnosis of compression was 17 days. There were 16 patients with neurological deficit, including 5 with paraplegia. Specific imaging procedures were performed in 16 patients. Treatment included operation in 8 patients, followed by chemotherapy (6 patients) and/or radiotherapy (4 patients); 9 of the 10 non-operated patients received radiotherapy. Only 6 patients had a significant neurological improvement. All patients but 1 died within a median time of 2 months. Early diagnosis might prevent permanent disability in these children with a short survival expectancy. |
Authors:
|
E Bouffet; P Marec-Berard; P Thiesse; C Carrie; T Risk; A Jouvet; M Brunat-Mentigny; C Mottolese |
Related Documents
:
|
19515614 - Predicting outcomes for children with neuroblastoma using a multigene-expression signat... 9212844 - Trends of survival in neuroblastoma and independent risk factors for survival at a sing... 1779334 - Urinary dopamine/noradrenaline and dopamine/vanillylmandelic acid ratios as a reflectio... 1625134 - Therapeutic significance of surgery in advanced neuroblastoma: a report from the study ... 23108554 - Nuclear e-cadherin expression is associated with the loss of membranous e-cadherin, pla... 9140434 - Suramin in non-small cell lung cancer and advanced breast cancer. two parallel phase ii... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Volume: 13 ISSN: 0256-7040 ISO Abbreviation: Childs Nerv Syst Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1997-12-09 Completed Date: 1997-12-09 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8503227 Medline TA: Childs Nerv Syst Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 383-7 Citation Subset: IM |
Affiliation:
|
Department of Paediatric Oncology, Centre Léon Bérard, Lyon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Bone Neoplasms / pathology Brain Neoplasms / pathology Child Child, Preschool Female Humans Infant Kidney Neoplasms / pathology Male Neoplasm Staging Retrospective Studies Spinal Cord Compression / etiology* Spinal Cord Neoplasms / complications*, drug therapy, secondary* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spinal cord astrocytomas: long-term results comparing treatments in children.
Next Document: Prognosis of medulloblastoma in infants.