| Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20971097 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of type 2 diabetes patients, however, the molecular mechanisms underlying DNP remain unclear. Emerging research implicates the participation of spinal glial cells in some neuropathic pain models. However, it remains unknown whether spinal glial cells are activated under type 2 diabetic conditions and whether they contribute to diabetes-induced neuropathic pain. In the present study, using a db/db type 2 diabetes mouse model that displayed obvious mechanical allodynia, we found that spinal astrocyte but not microglia was dramatically activated. The mechanical allodynia was significantly attenuated by intrathecally administrated l-α-aminoadipate (astrocytic specific inhibitor) whereas minocycline (microglial specific inhibitor) did not have any effect on mechanical allodynia, which indicated that spinal astrocytic activation contributed to allodynia in db/db mice. Further study aimed to identify the detailed mechanism of astrocyte-induced allodynia in db/db mice. Results showed that spinal activated astrocytes dramatically increased interleukin (IL)-1β expression which may induce N-methyl-D-aspartic acid receptor (NMDAR) phosphorylation in spinal dorsal horn neurons to enhance pain transmission. Together, these results suggest that spinal activated astrocytes may be a crucial component of mechanical allodynia in type 2 diabetes and "Astrocyte-IL-1β-NMDAR-Neuron" pathway may be the detailed mechanism of astrocyte-induced allodynia. Thus, inhibiting astrocytic activation in the spinal dorsal horn may represent a novel therapeutic strategy for treating DNP. |
| | |
Authors:
|
Yong-Hui Liao; Gui-He Zhang; Dong Jia; Peng Wang; Nian-Song Qian; Fei He; Xiang-Tian Zeng; Yong He; Yan-Ling Yang; Da-Yong Cao; Yi Zhang; De-Sheng Wang; Kai-Shan Tao; Chang-Jun Gao; Ke-Feng Dou |
Related Documents
:
|
17089597 - Conditioning of tentacle lowering in the snail (helix aspersa): acquisition, latent inh... 7625557 - Effects of acute and repeated ethanol exposures on the locomotor activity of bxd recomb... 8719787 - Meta-chlorophenylpiperazine attenuates formalin-induced nociceptive responses through 5... 11797897 - Summary of stationary and personal air sampling measurements made during a plutonium gl... 12897167 - Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in r... 18938677 - Neuroanatomical correlates of executive functioning in depressed adults with type 2 dia... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-12 |
Journal Detail:
|
Title: Brain research Volume: 1368 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 324-35 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunocytochemical distribution of WARP (von Willebrand A domain-related protein) in the inner ear.
Next Document: Cellular plasticity in the supraoptic and paraventricular nuclei after prolonged dehydration in the ...