| Spinal MRI in patients with suspected multiple sclerosis and negative brain MRI. | |
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MedLine Citation:
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PMID: 8673484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although MRI detects the white matter lesions of multiple sclerosis within the brain with high sensitivity, a minority of patients have normal brain MRI. We describe 20 patients, selected from over 170 who had undergone brain imaging with minimal (n = 12) or no (n = 8) abnormalities (median number of lesions = I, range, 0-3) but in whom spinal MRI was abnormal. Twelve had clinically definite or laboratory supported definite multiple sclerosis according to the Poser criteria; one had clinically probable disease and seven, not fulfilling the Poser criteria, were classified as possible multiple sclerosis. All had presented with symptoms and signs referable to the spinal cord or optic nerves. Eleven had a primary progressive course, eight relapsing-remitting and only one secondary progressive. Moderate or severe disability was the rule in the primary progressive cases; all the relapsing-remitting patients had minimal disability. All had at least one lesion visible in the spinal cord (median 2; range 1-6). In patients in whom the diagnosis of multiple sclerosis is not supported by abnormalities on brain MRI, imaging of the spinal cord can be of considerable value. |
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Authors:
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J W Thorpe; D Kidd; I F Moseley; A J Thompson; D G MacManus; D A Compston; W I McDonald; D H Miller |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Brain : a journal of neurology Volume: 119 ( Pt 3) ISSN: 0006-8950 ISO Abbreviation: Brain Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-08-13 Completed Date: 1996-08-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372537 Medline TA: Brain Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 709-14 Citation Subset: AIM; IM |
Affiliation:
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NMR Research Unit, Institute of Neurology, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Diseases / diagnosis, pathology Disability Evaluation Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / diagnosis*, pathology Spinal Cord Diseases / diagnosis*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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