Document Detail

Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats.
MedLine Citation:
PMID:  23187120     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : The chemokine monocyte chemoattractant protein-1 (MCP-1) has been shown to contribute to neuropathic pain. However, whether MCP-1 is involved in the development of morphine antinociceptive tolerance is incompletely understood.
METHODS: : Morphine antinociceptive tolerance was induced by intrathecal administration of 15 μg of morphine daily for 7 days. Immunohistochemistry was used to test the changes in the morphology of spinal MCP-1 immunoreactivity and OX-42-IR. The role of MCP-1 in morphine antinociceptive tolerance is explored by hot-water tail-flick test.
RESULTS: : Our findings showed that intrathecal chronic morphine exposure obviously increased MCP-1 immunoreactivity in the spinal cord. Moreover, the increased MCP-1 immunoreactivity was observed mainly in the spinal neurons. Intrathecal injections of MCP-1-neutralizing antibody significantly reduced the development of morphine antinociceptive tolerance, suggesting that spinal neuronal MCP-1 contributes to tolerance to morphine antinociception. Treatment with MCP-1-neutralizing antibody also reduced the spinal microglial activation induced by chronic morphine treatment.
CONCLUSIONS: : This study revealed for the first time that spinal neuronal MCP-1 is a key mediator of the spinal microglial activation and that spinal MCP-1 is involved in morphine antinociceptive tolerance. Inhibition of MCP-1 may provide a new therapy for morphine tolerance management.
Chun-Mei Zhao; Rui-Xian Guo; Fen Hu; Jin-Lan Meng; Li-Qiu Mo; Pei-Xi Chen; Xin-Xue Liao; Yu Cui; Jian-Qiang Feng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  344     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-9     Citation Subset:  AIM; IM    
Department of Physiology (CZ, RG, FH, JM, PC, YC, JF), Zhongshan Medical College, Sun Yat-sen University, Guangzhou, China; Department of Physiology (JM), Guangdong Pharmaceutical University, Guangzhou, China; and Departments of Anesthesia (LM) and Cardiovasology (XL), the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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