| Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats. | |
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MedLine Citation:
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PMID: 23187120 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: : The chemokine monocyte chemoattractant protein-1 (MCP-1) has been shown to contribute to neuropathic pain. However, whether MCP-1 is involved in the development of morphine antinociceptive tolerance is incompletely understood. METHODS: : Morphine antinociceptive tolerance was induced by intrathecal administration of 15 μg of morphine daily for 7 days. Immunohistochemistry was used to test the changes in the morphology of spinal MCP-1 immunoreactivity and OX-42-IR. The role of MCP-1 in morphine antinociceptive tolerance is explored by hot-water tail-flick test. RESULTS: : Our findings showed that intrathecal chronic morphine exposure obviously increased MCP-1 immunoreactivity in the spinal cord. Moreover, the increased MCP-1 immunoreactivity was observed mainly in the spinal neurons. Intrathecal injections of MCP-1-neutralizing antibody significantly reduced the development of morphine antinociceptive tolerance, suggesting that spinal neuronal MCP-1 contributes to tolerance to morphine antinociception. Treatment with MCP-1-neutralizing antibody also reduced the spinal microglial activation induced by chronic morphine treatment. CONCLUSIONS: : This study revealed for the first time that spinal neuronal MCP-1 is a key mediator of the spinal microglial activation and that spinal MCP-1 is involved in morphine antinociceptive tolerance. Inhibition of MCP-1 may provide a new therapy for morphine tolerance management. |
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Authors:
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Chun-Mei Zhao; Rui-Xian Guo; Fen Hu; Jin-Lan Meng; Li-Qiu Mo; Pei-Xi Chen; Xin-Xue Liao; Yu Cui; Jian-Qiang Feng |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 344 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 473-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology (CZ, RG, FH, JM, PC, YC, JF), Zhongshan Medical College, Sun Yat-sen University, Guangzhou, China; Department of Physiology (JM), Guangdong Pharmaceutical University, Guangzhou, China; and Departments of Anesthesia (LM) and Cardiovasology (XL), the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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