Document Detail

Spillover of Fatty Acids during Dietary Fat Storage in Type 2 Diabetes: Relationship to Body Fat Depots and Effects of Weight Loss.
MedLine Citation:
PMID:  23349503     Owner:  NLM     Status:  Publisher    
Spillover of lipoprotein lipase-generated fatty acids from chylomicrons into the plasma free fatty acid (FFA) pool is an important source of FFA and reflects inefficiency in dietary fat storage. We measured spillover in people with type 2 diabetes (n = 13) using infusions of a [(3)H] triolein-labeled lipid emulsion and [U-(13)C] oleate during continuous feeding, before and after weight loss. Body fat was measured with dual energy X-ray absorptiometry and CT. Participants lost ∼14% of body weight. There was a ∼38% decrease in meal-suppressed FFA concentration (P< 0.0001) and a ∼23% decrease in oleate flux (P=0.007). Fractional spillover did not change (P=NS). At baseline, there was a strong negative correlation between spillover and leg fat (r =-0.79, P=0.001) and a positive correlation with trunk:leg fat ratio (R=0.56, P=0.047). These correlations disappeared after weight loss. Baseline leg fat (R=-0.61, P=0.027) but not trunk fat (R= - 0.27, P=0.38), negatively predicted decreases in spillover with weight loss. These results indicate that spillover, a measure of inefficiency in dietary fat storage, is inversely associated with lower body fat in type 2 diabetes.
Jaime P Almandoz; Ekta Singh; Lisa A Howell; Karen Grothe; Danielle T Vlazny; Almira Smailovic; Brian A Irving; Robert H Nelson; John M Miles
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Diabetes     Volume:  -     ISSN:  1939-327X     ISO Abbreviation:  Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Mayo Clinic, Endocrine Research Unit, Rochester, Minnesota, United States.
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