Document Detail

"Spiceophrenia": a systematic overview of "Spice"-related psychopathological issues and a case report.
MedLine Citation:
PMID:  23881886     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: The use of synthetic cannabimimetics (SC; "spice" drugs) is increasing, especially among teenagers and young adults. In parallel with this, the number of studies describing intoxication episodes associated with psychotic symptoms in SC users is growing. We present both a systematic review of the related literature and a case report, which seems to highlight the existence of a possible association between SC use and psychosis.
METHODS: Some 223 relevant studies were here identified and reviewed. Out of these, 120 full text articles were assessed for eligibility, and 41 were finally included in the systematic review.
RESULTS: According to the available data from the studies here identified, SC's average age of users was 22.97 years, and the male/female ratio was 3.16:1. SC compounds most often reported in studies using biological specimen analysis were JWH-018, JWH-073, JWH-122, CP-47,497, and JWH-250. Mounting evidence seemed to suggest that psychotic symptoms such as hallucinations and delusions may occur in acute/chronic SC users.
CONCLUSIONS: Although a clear causal link may not be here identified, the available evidence suggests that SC can trigger the onset of acute psychosis in vulnerable individuals and/or the exacerbation of psychotic episodes in those with a previous psychiatric history. Copyright © 2013 John Wiley & Sons, Ltd.
Duccio Papanti; Fabrizio Schifano; Giulia Botteon; Francesca Bertossi; Jason Mannix; Daniela Vidoni; Matteo Impagnatiello; Elisabetta Pascolo-Fabrici; Tommaso Bonavigo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human psychopharmacology     Volume:  28     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-89     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
University of Trieste Medical School, Psychiatry Residency School, Trieste, Italy; Community Mental Health Team Maddalena, Trieste, Italy.
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