Document Detail

Sphingosine and the transient receptor potential channel kinase(s).
MedLine Citation:
PMID:  23186176     Owner:  NLM     Status:  MEDLINE    
Transient receptor potential melastatin 7 (TRPM7) is a multifunctional ion channel playing crucial roles during development. TRPM7 is a member of the highly diverse TRP ion channel family. Most TRP channels are regulated by membrane phospholipids, especially phosphoinositides. In this issue of the British Journal of Pharmacology, Qin et al. describes the regulation of TRPM7 and its close homologue TRPM6 by a different kind of membrane lipid: sphingosine. The study finds that sphingosine is a potent and specific inhibitor of TRPM7 and TRPM6 channels. This commentary briefly summarizes the findings of the study, their potential significance and discusses open question and future directions.
Tibor Rohacs
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  168     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-08-23     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1291-3     Citation Subset:  IM    
Copyright Information:
© 2012 The Author. British Journal of Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Membrane Potentials / drug effects*
Membrane Transport Modulators / pharmacology*
Myocytes, Cardiac / drug effects*
Propylene Glycols / pharmacology*
Protein Kinase Inhibitors / pharmacology*
Sphingosine / analogs & derivatives*,  metabolism*,  pharmacology
TRPM Cation Channels / antagonists & inhibitors*
Reg. No./Substance:
0/Membrane Transport Modulators; 0/Propylene Glycols; 0/Protein Kinase Inhibitors; 0/TRPM Cation Channels; 3QN8BYN5QF/fingolimod; EC 2.7.1.-/TRPM7 protein, human; NGZ37HRE42/Sphingosine
Comment On:
Br J Pharmacol. 2013 Mar;168(6):1294-312   [PMID:  23145923 ]

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