Document Detail

Sphingosine-1-phosphate regulation of mammalian development.
MedLine Citation:
PMID:  18675379     Owner:  NLM     Status:  MEDLINE    
Sphingosine-1-phosphate (S1P) was first identified as a lysophospholipid metabolite whose formation is required for the irreversible degradation of sphingolipids. Years later, it was discovered that S1P is a bioactive lipid that provokes varied cell responses by acting through cell-surface receptors to drive cell signaling. More recent findings in model organisms have now established that S1P metabolism and signaling are integrated into many physiological systems. We describe here the surprising breadth of function of S1P in mammalian development and the underlying biologic processes that S1P regulates.
Mari Kono; Maria Laura Allende; Richard L Proia
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-07-14
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1781     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  435-41     Citation Subset:  IM    
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1821, USA.
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MeSH Terms
Cell Movement
Central Nervous System / metabolism
Embryo, Mammalian / embryology,  metabolism
Lysophospholipids / metabolism*
Mammals / embryology,  growth & development*,  metabolism*
Signal Transduction
Sphingosine / analogs & derivatives*,  metabolism
Grant Support
Z01 DK056014-01/DK/NIDDK NIH HHS; Z01 DK056015-01/DK/NIDDK NIH HHS; Z01 DK056016-01/DK/NIDDK NIH HHS; Z01 DK056017-01/DK/NIDDK NIH HHS; Z01 DK056018-01/DK/NIDDK NIH HHS; Z01 DK056019-01/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Lysophospholipids; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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