| Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. | |
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MedLine Citation:
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PMID: 21740973 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been shown to alleviate disease burden in immune-mediated animal models of MS, and has been approved for treatment in clinical trials in patients with MS in the United States. While the immunological effects of FTY720 are well established, there is controversy in the literature regarding the contribution of FTY720 on myelin repair. Here, we directly assessed the impact of FTY720 on myelin repair in cuprizone and lysolecithin (LPC) demyelination models that have a minimal immunological component. FTY720 failed to promote remyelination in either animal model. These studies suggest that while FTY720 may be effective at modulating the immunological attack in MS, it may benefit from an add-on therapy to enhance the myelin repair required for long-term functional restoration in MS. |
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Authors:
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Yinghui Hu; Xinhua Lee; Benxiu Ji; Kevin Guckian; Daniel Apicco; R Blake Pepinsky; Robert H Miller; Sha Mi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: - ISSN: 1095-9327 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Biogen Idec Inc., Neuro-Discovery Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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