Document Detail

Sphingolipids and cell signaling: involvement in apoptosis and atherogenesis.
MedLine Citation:
PMID:  16903825     Owner:  NLM     Status:  MEDLINE    
This review considers various functional aspects of cell sphingolipids (sphingomyelin, ceramides) and lysosphingolipids (sphingosine-1-phosphate (S1P) and sphingosine phosphorylcholine). Good evidence now exists that they are actively involved in numerous cell-signaling processes. The enzymes responsible for formation and interconversion of cell sphingolipids (sphingomyelinases, ceramidase, sphingosine kinase, S1P-lyase) exhibit high sensitivity to various stimulating factors. This determines the content of individual cell sphingolipids and therefore the mode of cell response. Special attention is paid to preferential localization of sphingolipids in the rigid plasma membrane domains (rafts) coupled to many signal proteins. The suggestion is discussed that ceramide signaling may be based on the modification of fine molecular interactions in lipid rafts, resulting in its clusterization inducing the signal transduction. The review also highlights involvement of sphingolipids in cell proliferation, apoptosis, and in processes implicated to atherosclerosis.
O M Ipatova; T I Torkhovskaya; T S Zakharova; E M Khalilov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  71     ISSN:  0006-2979     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-22     Citation Subset:  IM    
Institute of Biomedical Chemistry, Moscow, 119121, Russia.
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MeSH Terms
Atherosclerosis / metabolism*
Cell Proliferation
Models, Biological
Signal Transduction* / physiology
Sphingolipids / metabolism*
Reg. No./Substance:

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