Document Detail

Spheroids and cell survival.
MedLine Citation:
PMID:  11033297     Owner:  NLM     Status:  MEDLINE    
In contrast to most traditional cell culture systems, spheroids represent a unique opportunity to recapitulate aspects of cell homeostasis and as such better reflect in vivo tumor biology. This review highlights recent spheroid-based studies which have defined a role for intercellular adhesion in dictating cellular fate. Critical roles for adhesion molecules, such as the integrin and cadherin families, have been established. In addition, it appears that components of the signaling pathways that control cellular proliferation may also influence the cellular decision to live or die. Further complexity arises from the action of soluble factors, like epidermal growth factor, and three-dimensional culture systems are providing insights into how integration of these multiple signals is achieved. Given that cellular adhesion may serve as a regulator of apoptosis, and in particular that correct receptor engagement can activate signaling pathways promoting cell survival, additional implications for our understanding of tumor biology are discussed.
R C Bates; N S Edwards; J D Yates
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  36     ISSN:  1040-8428     ISO Abbreviation:  Crit. Rev. Oncol. Hematol.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  61-74     Citation Subset:  IM    
Cancer Research Unit, Faculty of Medicine and Health Sciences, The University of Newcastle, NSW 2308, Newcastle, Australia.
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MeSH Terms
Cell Adhesion
Cell Communication*
Cell Culture Techniques / methods*
Cell Survival
Neoplasms / pathology*
Neoplasms, Experimental / pathology*
Spheroids, Cellular / pathology*

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