Document Detail

Spermatozoa repellent as a contraceptive.
MedLine Citation:
PMID:  455977     Owner:  NLM     Status:  MEDLINE    
Early report by Kopp et al. have demonstrated that p-nitrophenyl-glycerol (PNPG) is an effective antiswarming agent in Proteus and that this inhibition may have been caused by PNPG interfering with the negative chemotaxis mechanism in the organism. With an inverted capillary assay, designed to test the motility response of rat epididymal spermatozoa to various suspending conditions including those exposed to chemical gradient, PNPG was shown in this study to exhibit an inhibitory effect at slightly higher than 10(-5) M. Moreover, this inhibitory effect appears to have stemmed from spermatozoa being repelled by PNPG as indicated by the observation that significantly less spermatozoa swim into a gradient of PNPG. The possibility of using spermatozoa repellents as contraceptives is discussed.
W W Tso; W M Lee; M Y Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraception     Volume:  19     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
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MeSH Terms
Contraceptive Agents, Male / pharmacology*
Glycerol / analogs & derivatives*,  pharmacology
Nitrobenzenes / pharmacology*
Sperm Immobilizing Agents / pharmacology
Sperm Motility / drug effects
Reg. No./Substance:
0/Contraceptive Agents, Male; 0/Nitrobenzenes; 0/Sperm Immobilizing Agents; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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