| Spermatogenic and sperm quality differences in an experimental model of Metabolic Syndrome and Hypogonadal Hypogonadism. | |
| | |
MedLine Citation:
|
PMID: 21464116 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The synergistic effect of the co-morbidities that comprise metabolic syndrome is increasingly being recognised as an important contributor in the pathology of a broad spectrum of seemingly disparate conditions. In terms of male reproductive function however, beyond erectile dysfunction, little is known of the influence of this cohort (collectively or separately) on spermatogenesis and sperm quality. The aims of this study were to assess the reproductive tract of a metabolic syndrome animal model for detrimental changes, to determine whether a group of compounds (advanced glycation end products and their receptor) known to cause cell dysfunction and DNA damage were present and assess whether hypogonadotropic hypogonadism was the main contributing factor for the changes seen. Animals fed a high fat diet were found to have significantly increased cholesterol, triglycerides, blood glucose, mean arterial pressure and visceral fat levels. Whilst serum testosterone was decreased, no changes were seen in either testicular or epididymal histology. Immunolocalisation of Nε-carboxymethyl-lysine and the receptor for advanced glycation end products was found in the testes, epididymides and sperm of the two treated groups of animals however ELISA did not show any difference in protein levels. Similarly, assessment of sperm nDNA fragmentation by acridine orange test did not find significant differences in nDNA integrity. We conclude that the minimal effect on spermatogenesis and sperm quality seen in our model is probably due to the moderate increase of blood glucose rather than the hypogonadism. |
| | |
Authors:
|
Con Mallidis; Agnieszka Czerwiec; Sandra Filippi; Jason O'Neill; Mario Maggi; Neil McClure |
Related Documents
:
|
21291826 - Serum 25-hydroxyvitamin d is independently associated with high-density lipoprotein cho... 8185666 - Demonstration of a direct effect on hepatic acyl coa: cholesterol acyl transferase (aca... 1617286 - Inhibition of acat activity after 7-oxo-pgi2 treatment in cholesterol-fed rabbits. 187416 - Strain-dependent gonadal effects upon the response of adrenal cholesterol esters to act... 10837286 - Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. 2272656 - Changes in lipid profiles of brain of albino rats following envenomation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-4 |
Journal Detail:
|
Title: Reproduction (Cambridge, England) Volume: - ISSN: 1741-7899 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100966036 Medline TA: Reproduction Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
C Mallidis, Centre for Reproductive Medicine and Andrology, Westfälische Wilhelms-Universität Münster, Münster, 48149, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Prospective Polysomnographic Study on the Evolution of Complex Sleep Apnoea.
Next Document: Autophagy is a cell survival program for female germ cells in the murine ovary.