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Spermatocytic seminoma: toward further understanding of pathogenesis.
MedLine Citation:
PMID:  21725972     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Human germ cell tumours comprise a heterogeneous group of neoplasms which, based on pathobiological, genetic and clinical characteristics, can be subdivided into different entities. One of these subgroups relates to the so-called spermatocytic seminomas, benign tumours only found in the testis, preferentially in elderly men. Various developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma. A recent study examining expression of spermatogonial markers shows that spermatocytic seminomas are a heterogeneous group of tumours, with a supposed difference in origin, ie the majority from A$_{\rm{pale}}$ or B spermatogonia, and a minority from A$_{\rm{dark}}$ spermatogonia. However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors:
Leendert Hj Looijenga
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  224     ISSN:  1096-9896     ISO Abbreviation:  J. Pathol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Pathology, Erasmus MC University Medical Centre Rotterdam, The Netherlands. l.looijenga@erasmusmc.nl.
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