| Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. | |
| | |
MedLine Citation:
|
PMID: 15051328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mammalian testes are highly sensitive to oxidative free radical damage. Acute scrotum is a clinical syndrome mainly caused by torsion of the spermatic cord that constitutes a surgical emergence affecting newborns, children and adolescents. This syndrome often leads to infertility of the ipsilateral (torted) and contralateral (not torted) testis, an outcome that makes surgical intervention mandatory. There is a controversy involving the effects of ischemia and reperfusion on ipsilateral and contralateral testes after unilateral torsion and detorsion of the spermatic cord. Conflicting reports have led to two distinct and opposite recommendations regarding surgical intervention: detortion and preservation of the ipsilateral testis, or ipsilateral orchiectomy to preserve contralateral fertility. Early detortion surgery in humans preserves fertility, but after prolonged torsion periods followed by preservation of the ipsilateral fertility of both testis is jeopardized. Lowered contralateral blood flow after unilateral testicular torsion is associated with reactive oxygen species (ROS) overgeneration and therefore with the corresponding tissue damage. Reperfusion time appears to be determinant of contralateral testes damage due to the consequent oxidative insult that accompanies the rise in ROS following ischemia-reperfusion. Nevertheless, more investigations on the molecular mechanisms and the antioxidant status in testis are necessary to ascertain the contribution of ROS to the tissue damage produced by spermatic cord torsion in experimental animals and humans. |
| | |
Authors:
|
Danilo Wilhelm Filho; Moacir A Torres; André L B Bordin; Tânia B Crezcynski-Pasa; Alberto Boveris |
Related Documents
:
|
20867698 - Seeing in color: jet superstructure. 12578408 - The value of color flow doppler ultrasonography of the superior thyroid artery in the s... 8677148 - Regional cerebral blood flow estimates in newborn lamb using amplitude-mode color doppl... 7688708 - Transvaginal color and pulsed doppler assessment of adnexal tumor vascularity. 19290078 - Adverse reactions in blood and apheresis donors: experience from two italian transfusio... 21863368 - Magnetic resonance velocity mapping of 3d cerebrospinal fluid flow dynamics in hydrocep... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Molecular aspects of medicine Volume: 25 ISSN: 0098-2997 ISO Abbreviation: Mol. Aspects Med. Publication Date: 2004 Feb-Apr |
Date Detail:
|
Created Date: 2004-03-30 Completed Date: 2004-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7603128 Medline TA: Mol Aspects Med Country: England |
Other Details:
|
Languages: eng Pagination: 199-210 Citation Subset: IM |
Affiliation:
|
Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Cidade Universitaria, Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil. dawifi@ccb.ufsc.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Fertility / physiology Humans Male Oxidative Stress / physiology Reactive Nitrogen Species / metabolism* Reactive Oxygen Species / metabolism* Reperfusion Injury / physiopathology* Spermatic Cord Torsion / physiopathology* Testis / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Reactive Nitrogen Species; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidative stress and antioxidant defenses in ethanol-induced cell injury.
Next Document: Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasiti...