Document Detail

Sperm may be associated with subfertility independent of oocyte fertilization.
MedLine Citation:
PMID:  15864925     Owner:  NLM     Status:  MEDLINE    
In vitro fertilization-embryo transfer seems to be an effective treatment for unexplained infertility. Some IVF centers always perform intracytoplasmic sperm injection in these circumstances being concerned that fertilization failure may occur by conventional oocyte insemination. However, other IVF centers perform intracytoplasmic sperm injection on half of the oocytes and do conventional insemination on the other half. However, if the group with conventional oocyte insemination had a good fertilization rate, in the future intracytoplasmic sperm injection would not be performed. Other IVF centers would inseminate all the oocytes with conventional insemination and not consider intracytoplasmic sperm injection in the future unless there were poor fertilization rates. The aforementioned studies suggest that prior to considering conventional insemination that as a minimum the simple inexpensive hypo-osmotic swelling test be performed and strong consideration also be given to the sperm stress test and SCSA. Similarly, even though IUI is less risky and costly than IVF-ET, there still is a moderate expense and risk involved, especially when superovulation is used. Thus, consideration for performing these tests should also be given even prior to IUI. This is especially important for subnormal HOST scores where pretreatment of the sperm with the protein digestive enzyme chymotrypsin when preparing the sperm has been demonstrated to markedly improve pregnancy rates.
J H Check
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  32     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Chromatin / metabolism
Embryo, Mammalian / physiology
Fertilization in Vitro*
Oligospermia / complications
Osmotic Pressure
Pregnancy Outcome
Sperm Injections, Intracytoplasmic*
Sperm Motility / physiology
Spermatozoa / physiology*
Stress, Physiological
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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