| Sperm-egg fusion: events at the plasma membrane. | |
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MedLine Citation:
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PMID: 15591242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sperm-egg fusion is a cell-cell membrane fusion event essential for the propagation of sexually reproducing organisms. In gamete fusion, as in other fusion events, such as virus-cell and intracellular vesicle fusion, membrane fusion is a two-step process. Attachment of two membranes through cell-surface molecules is followed by the physical merger of the plasma membrane lipids. Recent progress has demonstrated an essential role for an oocyte tetraspanin, CD9, in mouse sperm-egg fusion, and a specific molecular site crucial for CD9 function has been identified. Absence of glycosylphosphatidylinositol-anchored proteins on the oocyte surface also results in loss of oocyte fusion competence in this gamete. These discoveries provide a strong starting point for the identification of additional proteins that have roles in sperm-egg fusion. |
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Authors:
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Kathryn K Stein; Paul Primakoff; Diana Myles |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cell science Volume: 117 ISSN: 0021-9533 ISO Abbreviation: J. Cell. Sci. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-07-07 Revised Date: 2006-03-10 |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
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Languages: eng Pagination: 6269-74 Citation Subset: IM |
Affiliation:
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Section of Molecular and Cellular Biology, School of Medicine, University of California Davis, Davis, CA 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD / metabolism Cell Membrane / physiology* Fertilization Humans Male Membrane Fusion Membrane Glycoproteins / metabolism Ovum Sperm-Ovum Interactions* Spermatozoa |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD9 antigen; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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