Document Detail

Sperm-egg fusion: events at the plasma membrane.
MedLine Citation:
PMID:  15591242     Owner:  NLM     Status:  MEDLINE    
Sperm-egg fusion is a cell-cell membrane fusion event essential for the propagation of sexually reproducing organisms. In gamete fusion, as in other fusion events, such as virus-cell and intracellular vesicle fusion, membrane fusion is a two-step process. Attachment of two membranes through cell-surface molecules is followed by the physical merger of the plasma membrane lipids. Recent progress has demonstrated an essential role for an oocyte tetraspanin, CD9, in mouse sperm-egg fusion, and a specific molecular site crucial for CD9 function has been identified. Absence of glycosylphosphatidylinositol-anchored proteins on the oocyte surface also results in loss of oocyte fusion competence in this gamete. These discoveries provide a strong starting point for the identification of additional proteins that have roles in sperm-egg fusion.
Kathryn K Stein; Paul Primakoff; Diana Myles
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cell science     Volume:  117     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-07-07     Revised Date:  2006-03-10    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  6269-74     Citation Subset:  IM    
Section of Molecular and Cellular Biology, School of Medicine, University of California Davis, Davis, CA 95616, USA.
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MeSH Terms
Antigens, CD / metabolism
Cell Membrane / physiology*
Membrane Fusion
Membrane Glycoproteins / metabolism
Sperm-Ovum Interactions*
Reg. No./Substance:
0/Antigens, CD; 0/CD9 antigen; 0/Membrane Glycoproteins

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