| Sperm DNA fragmentation negatively correlates with velocity and fertilization rates but might not affect pregnancy rates. | |
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MedLine Citation:
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PMID: 16009168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate sperm DNA fragmentation in correlation with sperm parameters and IVF/intracytoplasmic sperm injection (ICSI) outcomes. DESIGN: Retrospective review. SETTING: A tertiary infertility referral clinic. PATIENT(S): We collected 303 semen samples from patients undergoing IVF with or without ICSI. INTERVENTION(S): Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assay, measurement of fertilization rates, good embryo rates, and pregnancy rates for the IVF/ICSI program. MAIN OUTCOME MEASURE(S): The percentage of sperm with DNA fragmentation, correlated with semen analysis parameters and IVF/ICSI outcomes. RESULT(S): Sperm DNA fragmentation rates were significantly higher in patients with abnormal sperm parameters than in those with normal sperm parameters. When sperm DNA fragmentation was >10%, fertilization rates were affected. Sperm DNA fragmentation rates were negatively correlated with sperm velocity parameters but did not affect pregnancy outcomes. CONCLUSION(S): The results indicated that sperm DNA fragmentation affects fertilization rates and sperm motility but might not affect pregnancy rates. |
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Authors:
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Chun-Chia Huang; David Pei-Cheng Lin; Hui-Mei Tsao; Tzu-Chun Cheng; Chung-Hsien Liu; Maw-Sheng Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 84 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-12 Completed Date: 2005-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 130-40 Citation Subset: IM |
Affiliation:
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Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA Fragmentation
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physiology* Female Humans Male Pregnancy Pregnancy Rate* Retrospective Studies Semen / physiology Sperm Motility / physiology* Spermatozoa / pathology*, physiology* Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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