Document Detail

Sperm DNA fragmentation negatively correlates with velocity and fertilization rates but might not affect pregnancy rates.
MedLine Citation:
PMID:  16009168     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate sperm DNA fragmentation in correlation with sperm parameters and IVF/intracytoplasmic sperm injection (ICSI) outcomes. DESIGN: Retrospective review. SETTING: A tertiary infertility referral clinic. PATIENT(S): We collected 303 semen samples from patients undergoing IVF with or without ICSI. INTERVENTION(S): Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assay, measurement of fertilization rates, good embryo rates, and pregnancy rates for the IVF/ICSI program. MAIN OUTCOME MEASURE(S): The percentage of sperm with DNA fragmentation, correlated with semen analysis parameters and IVF/ICSI outcomes. RESULT(S): Sperm DNA fragmentation rates were significantly higher in patients with abnormal sperm parameters than in those with normal sperm parameters. When sperm DNA fragmentation was >10%, fertilization rates were affected. Sperm DNA fragmentation rates were negatively correlated with sperm velocity parameters but did not affect pregnancy outcomes. CONCLUSION(S): The results indicated that sperm DNA fragmentation affects fertilization rates and sperm motility but might not affect pregnancy rates.
Chun-Chia Huang; David Pei-Cheng Lin; Hui-Mei Tsao; Tzu-Chun Cheng; Chung-Hsien Liu; Maw-Sheng Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  84     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-40     Citation Subset:  IM    
Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan.
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MeSH Terms
DNA Fragmentation / physiology*
Pregnancy Rate*
Retrospective Studies
Semen / physiology
Sperm Motility / physiology*
Spermatozoa / pathology*,  physiology*
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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