Document Detail


Speed of onset and offset and mechanisms of ventilatory depression from sevoflurane: an experimental study in the cat.
MedLine Citation:
PMID:  10201685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Inhalational anesthetics depress breathing dose dependently. The authors studied the dynamics of ventilation on changes in end-tidal sevoflurane partial pressure. To learn more about the mechanisms of sevoflurane-induced respiratory depression, the authors also studied its influence on the dynamic ventilatory response to carbon dioxide. METHODS: Experiments were performed in cats anesthetized with alpha chloralose-urethane. For protocol 1, step changes in end-tidal sevoflurane partial pressure were applied and inspired ventilation was measured. Breath-to-breath inspired ventilation was related to the sevoflurane concentration in a hypothetical effect compartment based on an inhibitory sigmoid Emax model. For protocol 2, step changes in the end-tidal partial pressure of carbon dioxide were applied at 0, 0.5, and 1% end-tidal sevoflurane. The inspired ventilation-end-tidal partial pressure of carbon dioxide data were analyzed using a two-compartment model of the respiratory controller, which consisted of a fast peripheral and slow central compartment. Values are the mean +/- SD. RESULTS: In protocol 1, the effect-site half-life of respiratory changes caused by alterations in end-tidal sevoflurane partial pressure was 3.6+/-1.0 min. In protocol 2, at 0.50% sevoflurane, the central and peripheral carbon dioxide sensitivities decreased to 43+/-20% and 36+/-18% of control. At 1% sevoflurane, the peripheral carbon dioxide sensitivity decreased further, to 12+/-13% of control, whereas the central carbon dioxide sensitivity showed no further decrease. CONCLUSIONS: Steady state inspired ventilation is reached after 18 min (i.e., 5 half-lives) on stepwise changes in end-tidal sevoflurane. Anesthetic concentrations of sevoflurane have, in addition to an effect on pathways common to the peripheral and central chemoreflex loops, a selective effect on the peripheral chemoreflex loop. Sevoflurane has similar effects on ventilatory control in humans and cats.
Authors:
A Dahan; E Olofsen; L Teppema; E Sarton; C Olievier
Related Documents :
9171125 - Laparoscopic cholecystectomy using abdominal wall retraction. hemodynamics and gas exch...
19346235 - Systemic recirculation assessed in apnoeic anaesthetized patients using carbon dioxide ...
3368995 - Transcutaneous measurement of pco2 at high ambient pressure (41 bar).
9277655 - A randomized comparison of gasless laparoscopy and co2 pneumoperitoneum.
9225145 - Ectasias of the subcapsular sinus in lymph nodes of athymic and euthymic rats: a relati...
15753735 - Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults wi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  90     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1119-28     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Leiden University Medical Center, The Netherlands. adahan@anst.azl.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / pharmacology*
Animals
Cats
Chemoreceptor Cells / physiology
Female
Male
Methyl Ethers / pharmacology*
Respiration / drug effects*
Respiratory Insufficiency / chemically induced*,  physiopathology
Time Factors
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute lung injury after instillation of human breast milk into rabbits' lungs: effects of pH and gas...
Next Document:  Effect of systemic morphine on the responses of convergent neurons to noxious heat stimuli applied o...