| Speed modulation of the continuous-flow total artificial heart to simulate a physiologic arterial pressure waveform. | |
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MedLine Citation:
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PMID: 20616704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study demonstrated the concept of using speed modulation in a continuous-flow total artificial heart (CFTAH) to shape arterial pressure waveforms and to adjust pressure pulsatility. A programmable function generator was used to determine the optimum pulsatile speed profile. Three speed profiles [sinusoidal, rectangular, and optimized (a profile optimized for generation of a physiologic arterial pressure waveform)] were evaluated using the CFTAH mock circulatory loop. Hemodynamic parameters were recorded at average pump speeds of 2,700 rpm and a modulation cycle of 60 beats per minute. The effects of varying physiologically relevant vascular resistance and lumped compliance on the hemodynamics were assessed. The feasibility of using speed modulation to manipulate systemic arterial pressure waveforms, including a physiologic pressure waveform, was demonstrated in vitro. The additional pump power consumption needed to generate a physiologic pulsatile pressure was 16.2% of the power consumption in nonpulsatile continuous-flow mode. The induced pressure waveforms and pulse pressure were shown to be very responsive to changes in both systemic vascular resistance and arterial compliance. This system also allowed pulsatile pulmonary arterial waveform. Speed modulation in the CFTAH could enable physicians to obtain desired pressure waveforms by simple manual adjustment of speed control input waveforms. |
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Authors:
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Akira Shiose; Kathleen Nowak; David J Horvath; Alex L Massiello; Leonard A R Golding; Kiyotaka Fukamachi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 56 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2011-01-04 Revised Date: 2012-03-14 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 403-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* Heart, Artificial* Models, Cardiovascular* Prosthesis Design / instrumentation* Pulsatile Flow / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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1R21HL089052/HL/NHLBI NIH HHS; R01 HL096619-03/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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