| Spectrum of radiological changes in hypertensive children with reversible posterior leucoencephalopathy. | |
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MedLine Citation:
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PMID: 17392398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We prospectively studied 19 children with severe hypertension to evaluate the spectrum of radiological changes, severity and reversibility of this entity. All of them were subjected to clinical and biochemical evaluation, followed by magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). Headache was seen in 17 children, 13 had confusion and drowsiness, 12 had nausea and vomiting, 10 patients had visual disturbances, seizure and dyspnoea. Only two had focal neurological deficit (one with right facial palsy and another with right lateral rectus palsy). Of these 19 children, 15 patients had hypertensive retinopathy and four had normal fundi. The positive MRI findings in 17/19 patients were: bilateral leukoencephalopathic changes in occipitoparietal region (9/17), diffuse white/grey matter lesion (3/17) patients, brain stem hyperintensity (2/17) and haemorrhagic lesions (3/17). On MRA, 12/19 patients had attenuation of cerebral arteries of different degree. On follow up, MRI findings resolved in all except three patients. All patients had normal MRA on follow up, except one with persistent minimal attenuation of middle cerebral artery and another had spasm in anterior, middle and posterior cerebral arteries. The intracranial abnormalities in these patients with severe hypertension were reversible in many of the cases after control of blood pressure was achieved. We therefore conclude that severe hypertension may lead to leuoencephalopathy, which had a wide radiological spectrum. A better understanding of this complex syndrome may obviate unnecessary investigations and allow management of associated problems in prompt and appropriate ways. |
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Authors:
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N Prasad; S Gulati; R K Gupta; K Sharma; K Gulati; R K Sharma; A Gupta |
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Publication Detail:
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Type: Journal Article Date: 2007-03-28 |
Journal Detail:
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Title: The British journal of radiology Volume: 80 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-08-08 Completed Date: 2007-09-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 422-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aortitis / complications, pathology, physiopathology Blood Pressure / physiology Brain / pathology Cerebral Angiography / methods Child Child, Preschool Female Glomerulonephritis / complications, pathology, physiopathology Humans Hypertension / complications, pathology*, physiopathology, radiography Hypertensive Encephalopathy / complications, pathology*, physiopathology, radiography Magnetic Resonance Angiography / methods Magnetic Resonance Imaging / methods Male Prospective Studies Syndrome |
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