Document Detail


Spectrum of neural electrical activity in guinea pig cochlea: effects of anaesthesia regimen, body temperature and ambient noise.
MedLine Citation:
PMID:  16310327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spectral analysis of electric noise recorded from the round window of the cochlea is thought to represent the summed spontaneous activity of the auditory nerve. It has been postulated that it could provide a possible tinnitus index. Because experimental conditions could change this neural activity, the effect of anaesthesia regimen, body temperature and ambient noise on the spectrum of spontaneous neural noise (SNN) were investigated in guinea pig cochlea. SNN was studied in awake guinea pigs and after anaesthesia with pentobarbital (P), xylazine/ketamine (XK) or xylazine/tiletamine-zolazepam (XTZ). Body temperature varied gradually from 33 to 41 degrees C under XK regimen. In awake animals, broadband noise was generated with intensity varying from 0 to 50 dB. The SNN consisted in a broad peak at approximately 900 Hz. With ambient broadband noise, it increased exponentially with the sound level with no shift in frequency. Soon after anaesthetic induction, the lowest frequencies were constantly decreased, and gradually the 900 Hz peak either increased moderately (P) or dropped steeply (XTZ) or remained unchanged (XK). Peak frequency increased linearly with body temperature whereas the amplitude reached a maximum at around 39.5 degrees C. In conclusion, these data indicate that experimental conditions such as anaesthesia regimen, body temperature and ambient noise modify the spontaneous neural outflow of the cochlea and must be taken into account when studying SNN.
Authors:
I Sendowski; F Raffin; D Clarençon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-28
Journal Detail:
Title:  Hearing research     Volume:  211     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-73     Citation Subset:  IM    
Affiliation:
Centre de recherches du service de santé des Armées (CRSSA), Département de radiobiologie, 24 avenue des Maquis du Grésivaudan BP 87, 38702, La Tronche Cedex, France. Isendowski@crssa.net
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Body Temperature / physiology
Cochlea / innervation*,  physiology*
Cochlear Nerve / physiology
Electrophysiology
Guinea Pigs
Humans
Noise
Otoacoustic Emissions, Spontaneous / physiology
Tinnitus / etiology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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