Document Detail


Spectrum of malignant lymphoma in Queen Elizabeth Hospital, Sabah.
MedLine Citation:
PMID:  15190631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphomas, ranked twelve among all cancers world-wide in the 1990s, in which it is more prevalent in males compared to females. A previous study on lymphomas in East Malaysia for a period of 3 years from 1981-1983 showed that the pattern of lymphomas conformed to the general pattern observed in Asia. Current study reviews lymphoma cases from the Department of Pathology, Queen Elizabeth Hospital, Sabah between 1997 and 1999, with the aim of investigating if the spectrum and pattern in Sabah has since changed, a decade later. A total of 91 confirmed lymphoma cases were phenotyped with a panel of antibodies and classified using the new WHO proposed list of lymphoid neoplasms. The 1981-1983 series was reviewed and cases reclassified accordingly for comparison. There are 83 (91.2%) NHL and 8 (8.8%) HL cases in this series, a ratio of NHL to HL of 9:1. Of the 83 cases of NHL, 66 (79.5%) were confirmed B-cell type, 13 (15.7%) T-phenotype, 1(1.2%) null cell type and one case unclassified. Diffuse large B-cell lymphoma is the most prevalent, (65.1%), followed by Burkitt's lymphoma and follicular lymphoma, (10.6%) each. Lymphoma pattern concurs with the previous series from Sabah, with higher prevalence of diffuse large cell lymphoma and lower incidence of follicular lymphoma and HL, as seen elsewhere in Asia. There is an overall increase in the number of cases of NHL in the 1990s. However, the proportion of T-NHL is reduced when compared to the series in the 1980s.
Authors:
S C Peh; J Shaminie; P Jayasurya; J Hiew
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Medical journal of Malaysia     Volume:  58     ISSN:  0300-5283     ISO Abbreviation:  Med. J. Malaysia     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-06-11     Completed Date:  2004-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361547     Medline TA:  Med J Malaysia     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  546-55     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Malaya, 50603 Kuala Lumpur.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Humans
Immunohistochemistry
In Situ Hybridization
Lymphoma / epidemiology*,  pathology
Malaysia / epidemiology
Male
Middle Aged

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