Document Detail

Spectrum of hemostatic derangements, in Budd-Chiari syndrome.
MedLine Citation:
PMID:  12696825     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome. METHODS: Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome. RESULTS: Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity. CONCLUSION: Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis.
Hara Prasad Pati; Sanjana Dayal; Amita Srivastava; Girish Kumar Pande; Subrat Kumar Acharya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  22     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-04-16     Completed Date:  2003-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  59-60     Citation Subset:  IM    
Department of Hematology, All India Institute of Medical Sciences, New Delhi 110 029.
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MeSH Terms
Budd-Chiari Syndrome / blood*
Liver Function Tests
Partial Thromboplastin Time

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