Document Detail


Spectrum of findings in a family with nonsyndromic autosomal dominant supravalvular aortic stenosis: a Doppler echocardiographic study.
MedLine Citation:
PMID:  2913119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonsyndromic familial supravalvular aortic stenosis is an autosomal dominant disorder. However, for many reported families, systematic study of all family members with echocardiographic or hemodynamic techniques has not been performed and degree of penetrance has not been assessed. The supravalvular stenosis in these family members usually is not associated with mental retardation or other characteristics of Williams syndrome. Although some believe that autosomal dominant supravalvular aortic stenosis is part of the spectrum of Williams syndrome, others believe that these are separate entities. Doppler echocardiograms were analyzed on 23 members of a 34 member family with several known to have supravalvular aortic stenosis; 20 studies were performed by the authors and 3 were done elsewhere and made available for review. No family member had mental retardation, characteristic facies or other findings of Williams syndrome. Three of the 34 had supravalvular aortic stenosis requiring surgery. Of 22 members examined echocardiographically who had not had prior surgical repair, 13 had supravalvular aortic stenosis. Echocardiographic findings ranged widely, from calcification of the ascending aorta in a 71 year old man with minimally increased flow velocity (1.7 m/s) to mild narrowing with mildly increased flow velocity in six members to significant narrowing with impressively increased flow velocity (2 to 4 m/s) in seven. In addition, four patients had mild narrowing of pulmonary artery branches and eight had peak pulmonary artery flow velocity above normal. This study demonstrates complete penetrance with extremely variable expression in this family with autosomal dominant supravalvular aortic stenosis and emphasizes the importance of using echocardiographic techniques in studying the family members who are suspected of having an inherited cardiovascular disease.
Authors:
G J Ensing; M A Schmidt; D J Hagler; V V Michels; G A Carter; R H Feldt
Related Documents :
7416629 - Experimental induction of intrinsic valve stenosis.
9485259 - Reconstruction of supravalvar aortic stenosis with autologous pulmonary artery.
6187209 - Emergency palliation of critical valvular aortic stenosis. a new application of prostag...
2617239 - Surgical management of congenital aortic stenosis in children and young adults.
1301249 - Reproducibility of measurements of coronary narrowings by videodensitometry and by digi...
11175069 - Thoracic aortic aneurysm presenting as pulmonary vein stenosis: a case presentation and...
8076049 - Tracheal approach to pulmonary artery sling associated with funnel-shaped tracheal sten...
18639169 - Traumatic carotid artery occlusion following blunt cervical injury.
23937759 - Venous arterialization for the treatment of large-area foot skin retrograde avulsion.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  13     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-09     Completed Date:  1989-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aortic Valve Stenosis / genetics*,  physiopathology
Child
Child, Preschool
Echocardiography, Doppler*
Female
Genes, Dominant
Heart Catheterization
Hemodynamics
Humans
Male
Middle Aged
Pedigree

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pulsatile diameter and elastic modulus of the aortic arch in essential hypertension: a noninvasive s...
Next Document:  Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia...