Document Detail


Spectrum of cytomorphological features, including literature review, of an extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q12) (TEC/EWS) results in one case.
MedLine Citation:
PMID:  18925568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon soft tissue sarcoma with evolving literature on its cytomorphological features and limited documentation of its molecular analysis. Herein, we present cytological features, including review, of four cases of an EMC. Smears were predominantly hypercellular, comprising tumor cells arranged in clusters, traberculae, and cords against a variable chondromyxoid background. Cells were mainly polygonal shaped with round to indented nuclei, uniform chromatin, displaying intranuclear inclusions, grooves, and eosinophilic to finely vacuolated cytoplasm. Three cases revealed presence of "rhabdoid" cells. All cases had histopathologic confirmation. One case displayed t(9;22)(q22;q12) translocation by fluorescent in situ hybridization (FISH), on smears.
Authors:
Rajiv Kumar; Bharat Rekhi; Nadia Shirazi; Anurita Pais; Pratibha Amare; Deepali Gawde; Nirmala Jambhekar
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  36     ISSN:  1097-0339     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-75     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Department of Pathology, Tata Memorial Hospital, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Neoplasms / genetics,  pathology*
Chondrosarcoma / genetics,  pathology*
Chromosomes, Human, Pair 22 / genetics*
Chromosomes, Human, Pair 9 / genetics*
Diagnosis, Differential
Humans
Male
Middle Aged
RNA-Binding Protein EWS / genetics*
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/RNA-Binding Protein EWS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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