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Spectrum of cognitive impairment in neurocysticercosis: Differences according to disease phase.
MedLine Citation:
PMID:  22402863     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:Cognitive decline related to neurocysticercosis (NC) remains poorly characterized and underdiagnosed. In a cross-sectional study with a prospective phase, we evaluated cognitive decline in patients with strictly calcified form (C-NC), the epidemiologically largest subgroup of NC, and investigated whether there is a spectrum of cognitive abnormalities in the disease. METHODS:Forty treatment-naive patients with C-NC aged 37.6 ± 11.3 years and fulfilling criteria for definitive C-NC were submitted to a comprehensive cognitive and functional evaluation and were compared with 40 patients with active NC (A-NC) and 40 healthy controls (HC) matched for age and education. Patients with dementia were reassessed after 24 months. RESULTS:Patients with C-NC presented 9.4 ± 3.1 altered test scores out of the 30 from the cognitive battery when compared to HC. No patient with C-NC had dementia and 10 patients (25%) presented cognitive impairment-no dementia (CIND). The A-NC group had 5 patients (12.5%) with dementia and 11 patients (27.5%) with CIND. On follow-up, 3 out of 5 patients with A-NC with dementia previously still presented cystic lesions with scolex on MRI and still had dementia. One patient died and the remaining patient no longer fulfilled criteria for either dementia or CIND, presenting exclusively calcified lesions on neuroimaging. CONCLUSIONS:Independently of its phase, NC leads to a spectrum of cognitive abnormalities, ranging from impairment in a single domain, to CIND and, occasionally, to dementia. These findings are more conspicuous during active vesicular phase and less prominent in calcified stages.
Authors:
C L Rodrigues; D C de Andrade; J A Livramento; L R Machado; R Abraham; L Massaroppe; L T Lucato; P Caramelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Departamento de Neurologia, Faculdade de Medicina (C.L.R., D.C.d.A., J.A.L., L.R.M., R.A.), Instituto do Câncer do Estado de São Paulo (ICESP) (D.C.d.A.), Departamento de Engenharia (L.M.), and Departamento de Radiologia (L.T.L.), Universidade de São Paulo; and Departamento de Clínica Médica (P.C.), Faculdade de Medicina da Universidade Federal de Minas Gerais Belo Horizonte (MG), Brazil.
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