Document Detail


Spectrum of central anticholinergic adverse effects associated with oxybutynin: comparison of pediatric and adult cases.
MedLine Citation:
PMID:  19732583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We reviewed Food and Drug Administration postmarketing reports of central nervous system (CNS) anticholinergic effects in association with oxybutynin. Taking domestic usage by age group into account, there is a disproportionately higher number of CNS adverse event cases reported in pediatric patients as compared with adult patients. CNS stimulation was prominent in the pediatric cases.
Authors:
Paula Gish; Andrew D Mosholder; Melissa Truffa; Rosemary Johann-Liang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-4     Citation Subset:  AIM; IM    
Affiliation:
Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, The United States Food and Drug Administration, Silver Spring, MD 20993, USA. paula.gish@fda.hhs.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Adverse Drug Reaction Reporting Systems / statistics & numerical data*
Age Factors
Central Nervous System / drug effects
Child
Child, Preschool
Databases as Topic
Humans
Infant
Mandelic Acids / administration & dosage,  adverse effects*
Middle Aged
Muscarinic Antagonists / administration & dosage,  adverse effects*
Nervous System Diseases / chemically induced*
Nocturnal Enuresis / drug therapy
Young Adult
Chemical
Reg. No./Substance:
0/Mandelic Acids; 0/Muscarinic Antagonists; 5633-20-5/oxybutynin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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