Document Detail

Spectrum of cardiac involvement in neonatal lupus.
MedLine Citation:
PMID:  20696015     Owner:  NLM     Status:  MEDLINE    
'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed.
L K Hornberger; N Al Rajaa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  72     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children's Hospital, Women's & Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Arrhythmias, Cardiac / congenital,  etiology,  pathology,  physiopathology
Atrioventricular Block / congenital,  etiology,  immunology,  pathology,  physiopathology
Cardiomyopathies / congenital,  etiology,  immunology,  pathology,  physiopathology
Heart Diseases / congenital,  etiology*,  immunology,  pathology,  physiopathology
Infant, Newborn
Infant, Newborn, Diseases / etiology*,  immunology,  pathology,  physiopathology
Lupus Erythematosus, Systemic / complications*,  congenital*,  immunology

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