| Spectrum of Respiratory Viruses in Children with Community Acquired Pneumonia. | |
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MedLine Citation:
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PMID: 22531244 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND.: Community-acquired pneumonia (CAP) remains a significant cause for childhood morbidity worldwide. We designed a study with the objective of describing the frequency of respiratory viruses, especially rhinovirus, human metapneumovirus (HMPV) and human bocavirus (HBoV) in hospitalized children with CAP. METHODS.: EA 6 year prospective study was conducted in children less than 14 years old admitted to the Pediatrics Department of the Severo Ochoa Hospital (Spain) with CAP. We studied the frequency of 16 respiratory viruses in nasopharyngeal aspirates. Clinical characteristics of RSV-only infections were compared with those of rhinovirus, HMPV and HBoV single infections. RESULTS.: A viral pathogen was identified in 649 (73.4%) of 884 hospitalized children with CAP. Viral coinfections were detected in 30%. The rate of viral detection was significantly greater in infants < 18 months (83%), than in older children (67%) (P< 0.001). The most frequently detected virus was RSV (41.6% of positive patients) followed by rhinovirus (26.2%), HBoV (17.8%), adenovirus (17.8%), HMPV (7%) and parainfluenza (7%). RSV was the most frequent virus in children less than 18 months, but rhinovirus was most common in the eldest group, <0.001. After stratifying by age, we found some significant differences among RSV, rhinovirus, HBoV and HMPV- associated infections. CONCLUSION.: The high prevalence of viral infections supports the role of respiratory viruses, mainly RSV, rhinovirus, HBoV and HMPV in CAP of children requiring hospitalization. These findings help us to understand the etiologic disease burden and to guide research and public health policy. |
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Authors:
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María Luz García-García; Cristina Calvo; Francisco Pozo; Patricia Ambrona Villadangos; Pilar Pérez-Breña; Inmaculada Casas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-23 |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: - ISSN: 1532-0987 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Pediatrics Department, Severo Ochoa Hospital. Madrid. Spain 2 Influenza and Respiratory Viruses Laboratory, National Center of Microbiology, Instituto de Salud Carlos III. Madrid. Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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