Document Detail

The spectrum of lung involvement in collagen vascular-like diseases following allogeneic hematopoietic stem cell transplantation: report of 6 cases and review of the literature.
MedLine Citation:
PMID:  21358437     Owner:  NLM     Status:  MEDLINE    
Multisystem autoimmune diseases occurring after allogeneic hematopoietic stem cell transplantation are infrequent, late-onset manifestations that resemble well-defined collagen vascular disorders. Because the lung is frequently involved in the course of connective tissue disorders, we focused on lung manifestations occurring in autoimmune diseases following allogeneic stem cell transplantation. In the present series, we report 6 patients with systemic lupus erythematous, mixed connective tissue disease, Sjögren syndrome, polymyositis, and ANCA-positive vasculitis who presented with a spectrum of pulmonary manifestations affecting the airways, lung parenchyma, and probably respiratory muscles. We identified 3 different histopathologic patterns of interstitial pneumonia consistent with the underlying autoimmune disorder: lymphocytic interstitial pneumonia and non-specific interstitial pneumonia in 2 patients with Sjögren syndrome and diffuse alveolar damage in 1 patient with ANCA-positive vasculitis. These lung manifestations had poor prognoses. Further studies are needed to determine the optimal therapy for these complications.
Anne Bergeron; Djaouida Bengoufa; Séverine Feuillet; Véronique Meignin; Régis Peffault de Latour; Michel Rybojad; Dominique Gossot; Elie Azoulay; Gérard Socié; Abdellatif Tazi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicine     Volume:  90     ISSN:  1536-5964     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-04-26     Revised Date:  2012-07-23    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-57     Citation Subset:  AIM; IM    
Service de Pneumologie, Hôpital Saint-Louis, Université Paris 7, UFR Denis Diderot, Paris, France.
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MeSH Terms
Autoimmune Diseases / therapy*
Collagen Diseases / etiology,  physiopathology*
Hematopoietic Stem Cell Transplantation / adverse effects*
Lung Diseases, Interstitial / etiology,  physiopathology*
Lupus Erythematosus, Systemic / etiology,  physiopathology
Middle Aged
Mixed Connective Tissue Disease / etiology,  physiopathology
Polymyositis / etiology,  physiopathology
Sjogren's Syndrome / etiology,  physiopathology
Time Factors
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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