| Spectrotypic analysis of antibodies to Helicobacter pylori in patients with antral gastritis and duodenal ulcer. | |
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MedLine Citation:
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PMID: 8567998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the anti Helicobacter pylori (H pylori) spectrotype associated with (a) antral gastritis and duodenal ulcer; (b) the H pylori eradicating treatment. METHODS: Spectrotypic analysis was performed by isoelectric focusing and reverse blotting (IEFRB) in a cross sectional study on sera from 70 patients with antral gastritis and duodenal ulcer. In addition, a longitudinal study was performed on 40 of these patients (20 with antral gastritis and 20 with duodenal ulcer) who underwent eradicating treatment. RESULTS: The cross sectional study showed that the oligoclonal spectrotype was present in 74% of antral gastritis patients and in 85% of duodenal ulcer patients. In only a minority of subjects (23% with antral gastritis and 3% with duodenal ulcer) was a polyclonal spectrotype observed. The longitudinal study showed a reduction in the intensity of the spectrotypic bands in 5/10 antral gastritis patients with eradicated H pylori as opposed to only 2/10 patients without eradication. A reduction was also observed in 6/11 eradicated v 0/9 non-eradicated patients with duodenal ulcer. Collectively, a reduction in the spectrotype was observed in 11/21 patients (52%) who--independently of the disease--underwent H pylori eradication, as opposed to 2/19 of the non-responder patients (10.5%). The polyclonal spectrotype was found exclusively in four patients with antral gastritis, all belonging to the group without eradication of H pylori after eradicating treatment. CONCLUSIONS: The anti H pylori oligoclonal spectrotype is the most common pattern observed in patients with antral gastritis and duodenal ulcer. After H pylori eradicating treatment the spectrotype does not change qualitatively, but the polyclonal pattern seems to be predictive of a poor response to eradication. |
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Authors:
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R Biselli; D Vaira; R Nisini; M Miglioli; L Menegatti; L Barbara; R D'Amelio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 48 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-03-06 Completed Date: 1996-03-06 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1117-21 Citation Subset: AIM; IM |
Affiliation:
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Italian Air Force, DASRS, Laboratory of Immunology, Pratica di Mare, Rome. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Bacterial / blood*, classification Cross-Sectional Studies Duodenal Ulcer / immunology*, microbiology Female Follow-Up Studies Gastritis / immunology*, microbiology Helicobacter Infections / drug therapy, immunology Helicobacter pylori / immunology* Humans Immunoblotting Isoelectric Focusing Longitudinal Studies Male Middle Aged Pyloric Antrum |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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