| Spectroscopic metabolic abnormalities in mTLE with and without MRI evidence for mesial temporal sclerosis using hippocampal short-TE MRSI. | |
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MedLine Citation:
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PMID: 12823584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Long echo time (TE) spectroscopy reliably identifies the epileptogenic hippocampus in mesial temporal lobe epilepsy. Short-TE spectroscopy gives additional metabolic information but may have more artifacts. The aim of this study was to test (a) lateralization of the seizure focus by short-TE spectroscopy, and (b) value of myoinositol (MI) in the identification of the epileptogenic hippocampus. METHODS: Twenty-four patients with temporal lobe epilepsy: 16 with mesial temporal sclerosis (TLE-MTS), eight patients with normal magnetic resonance imaging (MRI; TLE-No), and 16 controls were studied with hippocampal 2D short-TE magnetic resonance spectroscopic imaging (MRSI). RESULTS: In TLE-MTS, the ipsilateral N-acetylaspartate (NAA) was decreased compared with contralateral (p = 0.03) or controls (p = 0.007). Additionally, the ipsilateral MI was decreased compared with controls (p = 0.012). TLE-No values showed no side differences and were not different from controls. Abnormalities in the anterior hippocampus correctly lateralized the epileptogenic hippocampus in </=82% of TLE-MTS and in </=80% of the TLE-No. CONCLUSIONS: The accuracy of short-TE MRSI at 1.5 T for focus lateralization in mTLE is comparable to that of long-TE MRSI. MI might be helpful for focus lateralization, but more information about the factors influencing the MI concentration is needed. |
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Authors:
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Susanne G Mueller; Kenneth D Laxer; Joyce Suhy; Ria C Lopez; Derek L Flenniken; Michael W Weiner |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Epilepsia Volume: 44 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-25 Completed Date: 2003-09-24 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 977-80 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs (DVA) Medical Center, Magnetic Resonance Spectroscopy Unit Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, California 94115, U.S.A. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives*, metabolism Choline / metabolism Creatine / metabolism Diagnosis, Differential Dominance, Cerebral / physiology Energy Metabolism / physiology* Epilepsy, Temporal Lobe / diagnosis, physiopathology* Female Hippocampus / pathology, physiopathology* Humans Inositol / metabolism Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy* Male Middle Aged Predictive Value of Tests Reference Values Sclerosis |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS031966-14/NS/NINDS NIH HHS; R01-NS31966/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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