| Spectroscopic imaging of radiation-induced effects in the white matter of glioma patients. | |
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MedLine Citation:
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PMID: 11027879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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External radiation therapy of brain tumors may cause adverse effects on normal brain tissue, resulting in severe neuropsychological and cognitive impairment. We investigated the late delayed radiation effects in the white matter (WM) using (1)H magnetic resonance spectroscopic imaging ((1)HMRSI). Nine glioma patients with local radiation-induced signal abnormalities in the T(2)-weighted MR images were studied with nine age- and sex-matched controls. The metabolite ratios in the radiation-induced hyper intensity area (RIHA) and in the normal appearing white matter (NAWM) of the patients were compared with respective WM areas of the controls. In RIHA, choline/creatine (Cho/Cr) was 17% decreased (1.22 +/- 0.13 vs 1.47 +/- 0.16, p = 0.0027, significant (s), unpaired Student's t test with Bonferroni correction) in the patients compared to the controls, while there was no difference in N-acetyl aspartate/Cr (NAA/Cr) (2.49 +/- 0.57 vs 2.98 +/- 0.32, p = 0.039) or NAA/Cho (2. 03 +/- 0.40 vs 2.04 +/- 0.17, p = 0.95). In NAWM, Cho/Cr was 24% decreased (1.21 +/- 0.15 vs 1.59 +/- 0.13, p < 0.0001, s) and NAA/Cho was 20% increased (2.49 +/- 0.49 vs 1.98 +/- 0.15, p = 0. 0082, s) in the patients compared to the controls, while there was no difference in NAA/Cr (2.99 +/- 0.46 vs 3.16 +/- 0.32, p = 0.38). NAA(RIHA)/NAA(NAWM) was 25% decreased (0.75 +/- 0.20 vs 1.00 +/- 0. 12, p = 0.0043, s) and Cr(RIHA)/Cr(NAWM) was 16% decreased (0.89 +/- 0.15 vs 1.06 +/- 0.10, p = 0.013, s) in the patients compared to the controls, while there was no difference in Cho(RIHA)/Cho(NAWM) (0.92 +/- 0.23 vs 0.98 +/- 0.10, p = 0.47). (1)HMRSI reveals widespread chemical changes in the WM after radiation therapy. In RIHA, there is loss of NAA, Cho, and Cr implying axonal and membrane damage and in NAWM, there is loss of Cho, reflecting membrane damage. |
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Authors:
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A Virta; N Patronas; R Raman; A Dwyer; A Barnett; S Bonavita; G Tedeschi; N Lundbom |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 18 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-12-15 Completed Date: 2000-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 851-7 Citation Subset: IM |
Affiliation:
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Neuroimaging Branch, NINDS, Clinical Center, National Institutes of Health, Bethesda, MD, USA. anevir@earthlink.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / pathology*, radiation effects* Brain Neoplasms / diagnosis*, radiotherapy* Cranial Irradiation / methods Female Follow-Up Studies Glioma / diagnosis*, radiotherapy* Humans Magnetic Resonance Spectroscopy / methods* Male Middle Aged Myelin Sheath / pathology Probability Radiation Dosage Reference Values Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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